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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.11.000
1jueFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.662
2bslFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.662
1jubFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.644
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.621
2djxFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.620
4ef9FMNDihydroorotate dehydrogenase (fumarate)/0.606
4wzhFMNDihydroorotate dehydrogenase (fumarate)/0.598
2djlFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.587
3c3nFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.584
3gyeFMNDihydroorotate dehydrogenase (fumarate)/0.575
3oixFMNDihydroorotate dehydrogenase/0.529
1w6hTITPlasmepsin-23.4.23.390.486
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.473
2ifaFMNUncharacterized protein/0.472
1aa6MGDFormate dehydrogenase H1.1.99.330.467
3aezGDPPantothenate kinase2.7.1.330.466
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.464
3r96ACOMccE protein/0.463
1c7oPPGHemolysin/0.462
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.462
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.462
5hwsNAP2-dehydropantoate 2-reductase/0.462
3d91REMRenin3.4.23.150.460
2h2aDNDProbable nicotinate-nucleotide adenylyltransferase/0.459
2il2LIXRenin3.4.23.150.459
4g7gVFVLanosterol 14-alpha-demethylase/0.458
5dp2NAPCurF/0.458
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.457
1tqf32PBeta-secretase 13.4.23.460.456
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.456
3lqfNADGalactitol dehydrogenase/0.456
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.454
1bil0IURenin3.4.23.150.453
2g247IGRenin3.4.23.150.453
2iko7IGRenin3.4.23.150.453
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.452
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.452
3r7kFDAProbable acyl CoA dehydrogenase/0.452
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.452
3gw9VNILanosterol 14-alpha-demethylase/0.451
4eb7PLPCysteine desulfurase IscS 2/0.451
2g1r3IGRenin3.4.23.150.450
2zsaADPPantothenate kinase2.7.1.330.450
3ag6PAJPantothenate synthetase/0.450
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
4fqsLYAThymidylate synthase ThyA/0.450
2watCOAFatty acid synthase subunit alpha2.3.1.860.449
1udbUFGUDP-glucose 4-epimerase5.1.3.20.448
3isjA8DPantothenate synthetase6.3.2.10.448
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.448
4loi1YCStimulator of interferon genes protein/0.448
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.447
2zsbADPPantothenate kinase2.7.1.330.446
3ivgFG5Pantothenate synthetase6.3.2.10.446
3vswR31Renin3.4.23.150.446
4m83ERYOleandomycin glycosyltransferase2.4.10.446
4uymVOR14-alpha sterol demethylase Cyp51B/0.446
1cdoNADAlcohol dehydrogenase 11.1.1.10.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.444
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.444
2vhzNAIAlanine dehydrogenase1.4.1.10.444
3hyoADPPyridoxal kinase/0.444
3ske054Genome polyprotein2.7.7.480.444
4df2FMNNADPH dehydrogenase/0.444
4ips1G4Mycocyclosin synthase1.14.21.90.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.443
2po7CHDFerrochelatase, mitochondrial4.99.1.10.443
3qlsNDPDihydrofolate reductase1.5.1.30.443
4bfvZVVPantothenate kinase2.7.1.330.443
4frkDWDBeta-secretase 13.4.23.460.443
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.442
3owaFADAcyl-CoA dehydrogenase/0.442
3tjzGNPADP-ribosylation factor 1/0.442
4bftZVTPantothenate kinase2.7.1.330.442
4eb5PLPCysteine desulfurase IscS 2/0.442
4loh1SYStimulator of interferon genes protein/0.442
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.442
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.441
1x7gNAPPutative ketoacyl reductase1.3.10.441
1xddAAYIntegrin alpha-L/0.441
2g226IGRenin3.4.23.150.441
2oapANPType II secretion system protein (GspE-2)/0.441
2vprTDCTetracycline repressor protein class H/0.441
2ylrNAPPhenylacetone monooxygenase1.14.13.920.441
3r95ACOMccE protein/0.441
1g63FMNEpidermin decarboxylase4.1.10.440
1gesFADGlutathione reductase1.8.1.70.440
1xdpATPPolyphosphate kinase/0.440
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.440
3zeiAWHO-acetylserine sulfhydrylase/0.440
4la1FADThioredoxin glutathione reductase/0.440
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.440