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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1cnfFADNitrate reductase [NADH]1.7.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1cnfFADNitrate reductase [NADH]1.7.1.11.000
2cndFADNitrate reductase [NADH]1.7.1.10.606
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.575
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.554
2eixFADNADH-cytochrome b5 reductase/0.541
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.535
1j9zFADNADPH--cytochrome P450 reductase/0.505
1cneFADNitrate reductase [NADH]1.7.1.10.495
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.492
3tr05GPGuanylate kinase/0.472
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.469
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.467
2g247IGRenin3.4.23.150.463
2gv8NDPThiol-specific monooxygenase1.14.130.463
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.462
1x1aSAMC-20 methyltransferase/0.459
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.459
1bil0IURenin3.4.23.150.457
2c20NADUDP-glucose 4-epimerase/0.457
2g226IGRenin3.4.23.150.457
3nutSAHPrecorrin-3 methylase/0.457
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.452
1xe65FPPlasmepsin-23.4.23.390.451
5ah5LSSLeucine--tRNA ligase/0.450
1xe55FEPlasmepsin-23.4.23.390.449
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.449
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
2g1r3IGRenin3.4.23.150.448
3q9bB3NAcetylpolyamine amidohydrolase/0.448
4eb5PLPCysteine desulfurase IscS 2/0.448
2g1s4IGRenin3.4.23.150.447
2i4qUA4Renin3.4.23.150.444
4ke11R6Beta-secretase 13.4.23.460.444
1psa0ZLPepsin A3.4.23.10.443
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.440
2il2LIXRenin3.4.23.150.440
3p62FMNPentaerythritol tetranitrate reductase/0.440