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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bzlFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bzlFADTrypanothione reductase1.8.1.121.000
1febFADTrypanothione reductase1.8.1.120.599
4nevFADTrypanothione reductase/0.580
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.555
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.540
1gerFADGlutathione reductase1.8.1.70.536
3grsFADGlutathione reductase, mitochondrial1.8.1.70.533
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.533
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.531
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.521
1grhFADGlutathione reductase, mitochondrial1.8.1.70.521
1grgFADGlutathione reductase, mitochondrial1.8.1.70.520
2v6oFADThioredoxin glutathione reductase/0.520
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.519
4j56FADThioredoxin reductase 21.8.1.90.519
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.515
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.513
1greFADGlutathione reductase, mitochondrial1.8.1.70.512
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.512
1feaFADTrypanothione reductase1.8.1.120.511
1graFADGlutathione reductase, mitochondrial1.8.1.70.505
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.503
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.500
4jq9FADDihydrolipoyl dehydrogenase/0.496
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.490
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.486
2r9zFADGlutathione amide reductase/0.482
1geuFADGlutathione reductase1.8.1.70.479
2eq9FADDihydrolipoyl dehydrogenase/0.477
2wbaFADTrypanothione reductase1.8.1.120.477
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.476
1nhpFADNADH peroxidase1.11.1.10.474
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.473
2eq8FADDihydrolipoyl dehydrogenase/0.470
1zx9FADMercuric reductase1.16.1.10.466
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
1grbFADGlutathione reductase, mitochondrial1.8.1.70.459
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.459
1zk7FADMercuric reductase1.16.1.10.459
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.459
2hqmFADGlutathione reductase1.8.1.70.457
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.455
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.452
3icrFADCoenzyme A disulfide reductase/0.452
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.452
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.451
2yquFADDihydrolipoyl dehydrogenase/0.451
4dnaFADProbable glutathione reductase/0.451
3ic9FADPutative dihydrolipoamide dehydrogenase/0.450
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.449
3urhFADDihydrolipoyl dehydrogenase/0.449
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.448
1f8wFADNADH peroxidase1.11.1.10.445
1npxFADNADH peroxidase1.11.1.10.443
3ladFADDihydrolipoyl dehydrogenase/0.443
1nhsFADNADH peroxidase1.11.1.10.442
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.441
3nt6FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.440