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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/1.000
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.518
4pz2NADAldehyde dehydrogenase 2-6/0.516
4pxlNADAldehyde dehydrogenase3/0.506
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.503
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.30.498
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.494
4i3vNADAldehyde dehydrogenase (NAD+)/0.490
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.489
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.487
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.485
3iwkNADAminoaldehyde dehydrogenase/0.485
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.485
4wb9NAIRetinal dehydrogenase 11.2.1.360.484
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.482
3hazNADBifunctional protein PutA/0.482
1bpwNADBetaine aldehyde dehydrogenase1.2.1.80.481
1bxsNADRetinal dehydrogenase 11.2.1.360.481
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.481
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.481
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.480
4fr8NADAldehyde dehydrogenase, mitochondrial1.2.1.30.477
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.476
4zz7NADMethylmalonate-semialdehyde dehydrogenase/0.475
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.472
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.471
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.471
1o00NADAldehyde dehydrogenase, mitochondrial1.2.1.30.470
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.469
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.468
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.466
4x4lNAIRetinal dehydrogenase 11.2.1.360.466
1nzwNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.464
2jg7NADAntiquitin/0.464
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.463
5eyuNADBetaine-aldehyde dehydrogenase/0.461
3iwjNADAminoaldehyde dehydrogenase/0.460
4fr8ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.460
4oe2NAD2-aminomuconate 6-semialdehyde dehydrogenase/0.452
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.451
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.449
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.449
3lv1NAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.443
4pt0NADAldehyde dehydrogenase/0.441