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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1a8k0Q4Gag-Pol polyprotein3.4.23.16

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1a8k0Q4Gag-Pol polyprotein3.4.23.161.000
3ggaGGWGag-Pol polyprotein/0.590
3ekqROCGag-Pol polyprotein3.4.23.160.583
1ec3MS3Gag-Pol polyprotein3.4.23.160.574
2bqvA1AProtease/0.567
3s85LK0Gag-Pol polyprotein/0.567
3ekwDR7Gag-Pol polyprotein3.4.23.160.565
1ec2BEJGag-Pol polyprotein3.4.23.160.560
1hvsA77Gag-Pol polyprotein/0.560
3oxxDR7Gag-Pol polyprotein3.4.23.160.558
2aquDR7Gag-Pol polyprotein3.4.23.160.557
3ekyDR7Gag-Pol polyprotein3.4.23.160.557
3k4vROCGag-Pol polyprotein3.4.23.160.557
1hxwRITGag-Pol polyprotein/0.556
1k1u0Q4Gag-Pol polyprotein3.4.23.160.556
2xyfG40Gag-Pol polyprotein/0.556
1d4yTPVGag-Pol polyprotein3.4.23.160.555
3el1DR7Gag-Pol polyprotein3.4.23.160.555
3kfn3TLGag-Pol polyprotein/0.554
1zsr0ZTGag-Pol polyprotein3.4.23.160.553
3ggxGGXGag-Pol polyprotein/0.553
3o9cK20Pol polyprotein/0.553
1difA85Gag-Pol polyprotein/0.552
1ebwBEIGag-Pol polyprotein3.4.23.160.552
1zsf0ZSGag-Pol polyprotein3.4.23.160.552
1ffi2NCGag-Pol polyprotein3.4.23.160.551
1ivp1ZKGag-Pol polyprotein/0.551
2pk6O33V-1 protease/0.551
3kfr3TLGag-Pol polyprotein/0.551
1wbmBLLPol protein/0.550
2wl05AHGag-Pol polyprotein/0.550
3sa323XProtease/0.550
1fgc2NCGag-Pol polyprotein3.4.23.160.549
2wkz5AHGag-Pol polyprotein/0.549
3sa9A68Protease/0.548
3zptM8YGag-Pol polyprotein3.4.23.160.547
1hviA77Protease/0.546
1xl5190Gag-Pol polyprotein3.4.23.160.546
2q54MU1Protease/0.546
2uxzHI1Gag-Pol polyprotein3.4.23.160.546
3kf03TLGag-Pol polyprotein/0.546
1hxbROCGag-Pol polyprotein3.4.23.160.545
2bpy3INGag-Pol polyprotein3.4.23.160.545
3ndxRITGag-Pol polyprotein3.4.23.160.545
1rl8RITGag-Pol polyprotein3.4.23.160.544
3ndwRITGag-Pol polyprotein3.4.23.160.544
1w5yBE6Gag-Pol polyprotein3.4.23.160.543
1wbk568Pol protein/0.543
2qi3MZ5Gag-Pol polyprotein/0.543
3sa5A69Protease/0.543
2cem2AHPol protein/0.542
2p3b3TLV-1 PROTEASE protein/0.542
2p3b3TLV-1 protease/0.542
3oxcROCProtease/0.542
3s56ROCProtease/0.542
4hdfG52Gag-Pol polyprotein3.4.23.160.542
2nmyROCProtease/0.541
3el9DR7Gag-Pol polyprotein3.4.23.160.541
3kfs3TLGag-Pol polyprotein/0.541
1hvjA78Gag-Pol polyprotein/0.540
1hvlA76Gag-Pol polyprotein/0.540
1z1hHBBGag-Pol polyprotein3.4.23.160.540
3nxe2NCProtease/0.540
3ttp017Gag-Pol polyprotein3.4.23.160.540
4dqc017Gag-Pol polyprotein/0.540
1hihC20Gag-Pol polyprotein/0.539
3nu9478Gag-Pol polyprotein3.4.23.160.539
3o9bK2APol polyprotein/0.539
3s54017Protease/0.539
3zpsEQMGag-Pol polyprotein3.4.23.160.539
1daz0Q4Gag-Pol polyprotein3.4.23.160.538
1ohr1UNV-1 PROTEASE protein/0.538
1w5xBE5Gag-Pol polyprotein3.4.23.160.538
3tl9ROCGag-Pol polyprotein3.4.23.160.538
2qi5MZ7Gag-Pol polyprotein/0.537
3gi4K60Gag-Pol polyprotein/0.537
3gi6D78Gag-Pol polyprotein/0.537
3jw2017Gag-Pol polyprotein3.4.23.160.537
3ndtROCGag-Pol polyprotein3.4.23.160.537
1dw60Q4Gag-Pol polyprotein3.4.23.160.536
1yt9OISGag-Pol polyprotein/0.536
2aoe0Q4Gag-Pol polyprotein3.4.23.160.536
2rkfAB1Pol protein/0.536
2xyeCXGGag-Pol polyprotein/0.536
3kdcJZPGag-Pol polyprotein3.4.23.160.536
3zpuM8BGag-Pol polyprotein3.4.23.160.536
4kb9G79Protease/0.536
4ye3G04Gag-Pol polyprotein3.4.23.160.536
1hshMK1Gag-Pol polyprotein/0.535
2bpv1INGag-Pol polyprotein3.4.23.160.535
2bpz3INGag-Pol polyprotein3.4.23.160.535
2i4wKGQProtease/0.535
2pk5075Protease/0.535
3d1yROCGag-Pol polyprotein3.4.23.160.535
3nduROCGag-Pol polyprotein3.4.23.160.535
4djoMK5Pol polyprotein/0.535
1sdvMK1Gag-Pol polyprotein3.4.23.160.534
4djr0KJPol polyprotein/0.534
4njvRITProtease/0.534
1k2b0Q4Gag-Pol polyprotein3.4.23.160.533
1sbgIM1Gag-Pol polyprotein/0.533
3sa6F71Protease/0.533
1hiv1ZKGag-Pol polyprotein/0.532
1jld0PPGag-Pol polyprotein/0.532
2f3kRO1Protease/0.532
2fdd385Pol protein/0.532
2qd6065Gag-Pol polyprotein3.4.23.160.532
2qnnQN1Gag-Pol polyprotein3.4.23.160.532
3dcrKVSProtease/0.532
3i2l2NCProtease/0.532
3ok9G52Gag-Pol polyprotein3.4.23.160.532
4qgiROCGag-Pol polyprotein3.4.23.160.532
1b6mPI6Gag-Pol polyprotein3.4.23.160.531
1d4lPI9Gag-Pol polyprotein3.4.23.160.531
2a4fAAUV-1 protease/0.531
2fxeDR7Gag-Pol polyprotein3.4.23.160.531
2hs2017Protease/0.531
2uy0HV1Gag-Pol polyprotein3.4.23.160.531
3sa755AProtease/0.531
3sacAF8Protease/0.531
1ec1BEEGag-Pol polyprotein3.4.23.160.530
1z1rHBHGag-Pol polyprotein3.4.23.160.530
2qd8065Gag-Pol polyprotein3.4.23.160.530
3a2oKNJGag-Pol polyprotein3.4.23.160.530
1b6lPI4Gag-Pol polyprotein3.4.23.160.529
2ieo017Protease/0.529
4djpM73Pol polyprotein/0.529
4dqh017Gag-Pol polyprotein/0.529
1a8g2Z4Gag-Pol polyprotein3.4.23.160.528
1b6pPI7Gag-Pol polyprotein3.4.23.160.528
1ebyBEBGag-Pol polyprotein3.4.23.160.528
2avm2NCGag-Pol polyprotein3.4.23.160.528
2qnpQN2Gag-Pol polyprotein3.4.23.160.528
3el4ROCGag-Pol polyprotein3.4.23.160.528
1a940Q4Gag-Pol polyprotein3.4.23.160.527
1fff0Q4Gag-Pol polyprotein3.4.23.160.527
2cej1AHPol protein/0.527
2qhyMZ1Gag-Pol polyprotein/0.527
3ekp478Gag-Pol polyprotein3.4.23.160.527
3ekv478Gag-Pol polyprotein3.4.23.160.527
3nyg2NCGag-Pol polyprotein3.4.23.160.527
3o9dK19Pol polyprotein/0.527
3o9eA60Pol polyprotein/0.527
1ec0BEDGag-Pol polyprotein3.4.23.160.526
2avvMK1Gag-Pol polyprotein3.4.23.160.526
2fxdDR7Pol polyprotein/0.526
2idw017Protease/0.526
2nnkROCProtease/0.526
4dqb017Gag-Pol polyprotein/0.526
1odw0E8Gag-Pol polyprotein3.4.23.160.525
3mxeK54Gag-Pol polyprotein3.4.23.160.525
1fg80Q4Gag-Pol polyprotein3.4.23.160.524
2cen4AHProtease/0.524
3ekx1UNGag-Pol polyprotein3.4.23.160.524
4dfg0JVGag-Pol polyprotein3.4.23.160.524
4hdpG52Gag-Pol polyprotein3.4.23.160.524
1d4kPI8Gag-Pol polyprotein3.4.23.160.523
1izhQ50Protease/0.523
2q5kAB1Protease/0.523
3em6017Gag-Pol polyprotein3.4.23.160.523
3qn8NI7Gag-Pol polyprotein3.4.23.160.523
4q1y017Gag-Pol polyprotein3.4.23.160.523
1d4iBEGGag-Pol polyprotein3.4.23.160.522
1hvkA79Gag-Pol polyprotein/0.522
2a1eIPFGag-Pol polyprotein3.4.23.160.522
2avsMK1Gag-Pol polyprotein3.4.23.160.522
2bpxMK1Gag-Pol polyprotein3.4.23.160.522
2o4pTPVProtease/0.522
3cktYDPGag-Pol polyprotein3.4.23.160.522
4hdbG52Gag-Pol polyprotein3.4.23.160.522
4njt017Protease/0.522
1a9mU0EGag-Pol polyprotein/0.521
2fleAIProtease/0.521
2qi7MZ9Gag-Pol polyprotein/0.521
2qnqQN3Gag-Pol polyprotein3.4.23.160.521
2r5q1UNGag-Pol polyprotein/0.521
3d1xROCGag-Pol polyprotein3.4.23.160.521
3linE13Protease/0.521
1fej2NCGag-Pol polyprotein3.4.23.160.520
3bva2NCGag-Pol polyprotein3.4.23.160.520
3vf5031Gag-Pol polyprotein3.4.23.160.520
1b6kPI5Gag-Pol polyprotein3.4.23.160.519
1mtrPI6Gag-Pol polyprotein3.4.23.160.519
2psuMUUProtease/0.519
2r5pMK1Gag-Pol polyprotein/0.519
3sa4F72Protease/0.519
1iziQ50Gag-Pol polyprotein3.4.23.160.518
1sdtMK1Gag-Pol polyprotein3.4.23.160.518
1sduMK1Gag-Pol polyprotein3.4.23.160.518
2q631UNGag-Pol polyprotein3.4.23.160.518
3em4DR7Gag-Pol polyprotein3.4.23.160.518
3tog079Gag-Pol polyprotein2.7.7.490.518
4rvj478Protease/0.518
1c6zROCProtease/0.517
1w5vBE3Gag-Pol polyprotein3.4.23.160.517
4njuTPVProtease/0.517
1bai0Q4Gag-Pro polyprotein/0.516
1vijBAYGag-Pol polyprotein/0.516
2p3d3TLProtease/0.516
2pym1UNGag-Pol polyprotein3.4.23.160.516
2z4o065Gag-Pol polyprotein3.4.23.160.516
3nu4478Gag-Pol polyprotein3.4.23.160.516
4a4qUX9Pol protein/0.516
1hsgMK1Gag-Pol polyprotein/0.515
1vikBAYGag-Pol polyprotein/0.515
2b7zMK1Gag-Pol polyprotein/0.515
2fde385Gag-Pol polyprotein3.4.23.160.515
2i4xKGQProtease/0.515
2pyn1UNGag-Pol polyprotein3.4.23.160.515
2qd7065Gag-Pol polyprotein3.4.23.160.515
3pwm017Gag-Pol polyprotein3.4.23.160.515
1m0b0ZQGag-Pol polyprotein3.4.23.160.514
2bpw1INGag-Pol polyprotein3.4.23.160.514
2hb3GRLProtease/0.514
2q641UNGag-Pol polyprotein3.4.23.160.514
2qak1UNGag-Pol polyprotein3.4.23.160.514
2qhcAB1Protease/0.514
3bvb017Gag-Pol polyprotein3.4.23.160.514
3st5G89Gag-Pol polyprotein3.4.23.160.514
4djqM86Pol polyprotein/0.514
1ebzBECGag-Pol polyprotein3.4.23.160.513
1fg62NCGag-Pol polyprotein3.4.23.160.513
1hosPHPGag-Pol polyprotein/0.513
1n49RITGag-Pol polyprotein3.4.23.160.513
1tcxIM1Gag-Pol polyprotein3.4.23.160.513
2qi0MZ3Gag-Pol polyprotein/0.513
3bgbLJGGag-Pol polyprotein3.4.23.160.513
3el51UNGag-Pol polyprotein/0.513
3s43478Protease/0.513
1iiq0ZRGag-Pol polyprotein3.4.23.160.512
2i4vDJRV-1 protease/0.512
2pqzG0GGag-Pol polyprotein3.4.23.160.512
2qi6MZ8Gag-Pol polyprotein/0.512
3o99K13Pol polyprotein/0.512
3o9iA61Gag-Pol polyprotein/0.512
1bdrIM1Gag-Pol polyprotein3.4.23.160.511
1ida0POGag-Pol polyprotein3.4.23.470.511
2ien017Gag-Pol polyprotein3.4.23.160.511
3d20017Gag-Pol polyprotein3.4.23.160.511
3ekt017Gag-Pol polyprotein3.4.23.160.511
3em3478Gag-Pol polyprotein3.4.23.160.511
3hzc2NCProtease/0.511
3oxv478Gag-Pol polyprotein3.4.23.160.511
3qaaG04Gag-Pol polyprotein3.4.23.160.511
3sabF78Protease/0.511
3uhl2NCGag-Pol polyprotein3.4.23.160.511
1t3r017Gag-Pol polyprotein3.4.23.160.510
2bb9AKCGag-Pol polyprotein3.4.23.160.510
2f81017Gag-Pol polyprotein3.4.23.160.510
2nnpROCProtease/0.510
2psvMUVProtease/0.510
3cyxROCGag-Pol polyprotein3.4.23.160.510
3nls016Gag-Pol polyprotein3.4.23.160.510
1ff02NCGag-Pol polyprotein3.4.23.160.509
1qbrXV6Gag-Pol polyprotein3.4.23.160.509
2f8g017Gag-Pol polyprotein3.4.23.160.509
2z54AB1Gag-Pol polyprotein3.4.23.160.509
4dqf017Gag-Pol polyprotein/0.509
2qhzMZ2Gag-Pol polyprotein/0.508
3dckKVIProtease/0.507
3nuo478Gag-Pol polyprotein3.4.23.160.507
1bwaXV6Gag-Pol polyprotein3.4.23.160.506
2aidTHKGag-Pol polyprotein3.4.23.160.506
2hc0AB2Protease/0.506
2qci065Gag-Pol polyprotein3.4.23.160.506
3o9fK2DGag-Pol polyprotein/0.506
3pwrROCGag-Pol polyprotein3.4.23.160.506
4hla017Gag-Pol polyprotein3.4.23.160.506
1k2c0Q4Gag-Pol polyprotein3.4.23.160.505
1sivPSIGag-Pol polyprotein/0.505
2q55MU0Protease/0.505
2r43G3GGag-Pol polyprotein3.4.23.160.505
3lzv017Gag-Pol polyprotein3.4.23.160.505
3nu5478Gag-Pol polyprotein3.4.23.160.505
3nuj478Gag-Pol polyprotein3.4.23.160.505
3nwq2NCGag-Pol polyprotein3.4.23.160.505
3toh079Gag-Pol polyprotein2.7.7.490.505
4k4p3TLGag-Pol polyprotein/0.505
1c6x3INProtease/0.504
1proA88Gag-Pol polyprotein/0.504
2f80017Gag-Pol polyprotein3.4.23.160.504
2i4uDJRProtease/0.504
3dk1G05Gag-Pol polyprotein3.4.23.160.504
3gi5K62Gag-Pol polyprotein/0.504
3mws017Pol protein/0.504
3o9gF53Gag-Pol polyprotein/0.504
3vf7031Gag-Pol polyprotein3.4.23.160.504
4dqe017Gag-Pol polyprotein/0.504
2b60RITPol polyprotein/0.503
3bxrDRRGag-Pol polyprotein3.4.23.160.503
3kddJZQGag-Pol polyprotein3.4.23.160.503
3lzs017Gag-Pol polyprotein3.4.23.160.503
3vfb031Gag-Pol polyprotein3.4.23.160.503
4gb20LQGag-Pol polyprotein2.7.7.490.503
1hpxKNIGag-Pol polyprotein/0.502
3saa77FProtease/0.502
2upjU02Gag-Pol polyprotein3.4.23.160.501
3jvy017Gag-Pol polyprotein3.4.23.160.501
3mxdK53Gag-Pol polyprotein3.4.23.160.501
4j5j478Gag-Pol polyprotein3.4.23.160.501
1npa3NHGag-Pol polyprotein3.4.23.160.500
1npwLGZGag-Pol polyprotein3.4.23.160.500
1t7i017Gag-Pol polyprotein3.4.23.160.500
2p3a3TLPol protein/0.500
2qi4MZ6Gag-Pol polyprotein/0.500
3jvwDMPGag-Pol polyprotein3.4.23.160.500
1msmJE2Gag-Pol polyprotein3.4.23.160.499
1muiAB1Protease/0.499
3i7eDJRGag-Pol polyprotein/0.499
3oxw017Gag-Pol polyprotein3.4.23.160.499
3vfa031Gag-Pol polyprotein3.4.23.160.498
1ajvNMBGag-Pol polyprotein3.4.23.160.497
1d4jMSCGag-Pol polyprotein3.4.23.160.497
1meuDMPGag-Pol polyprotein3.4.23.160.497
1t7kBH0Gag-Pol polyprotein3.4.23.160.497
3aidARQGag-Pol polyprotein3.4.23.160.497
1d4sTPVGag-Pol polyprotein3.4.23.160.496
1hiiC20Gag-Pol polyprotein/0.496
3nu6478Gag-Pol polyprotein3.4.23.160.496
3o9aK14Pol polyprotein/0.496
3o9hK2EGag-Pol polyprotein/0.496
1c70L75Protease/0.495
1sguMK1Gag-Pol polyprotein3.4.23.160.495
1sh9RITGag-Pol polyprotein3.4.23.160.495
2i0dMUTProtease/0.495
2q3kMUWGag-Pol polyprotein/0.495
3sa8K83Protease/0.495
4j55031Gag-Pol polyprotein3.4.23.160.495
4q1w017Gag-Pol polyprotein3.4.23.160.495
1g35AHFGag-Pol polyprotein3.4.23.160.494
1hwr216Gag-Pol polyprotein3.4.23.160.494
3fx5KNIGag-Pol polyprotein3.4.23.160.494
7upjINUGag-Pol polyprotein3.4.23.160.494
1g2kNM1Gag-Pol polyprotein3.4.23.160.493
1ivq0PXGag-Pol polyprotein/0.493
2i4dQFIProtease/0.493
2qi1MZ4Gag-Pol polyprotein/0.493
3djkG55Gag-Pol polyprotein3.4.23.160.493
1bdqIM1Gag-Pol polyprotein3.4.23.160.492
1qbu846Gag-Pol polyprotein3.4.23.160.492
3i6oGR6Gag-Pol polyprotein3.4.23.160.492
3liqE14Protease/0.492
3oy4017Gag-Pol polyprotein3.4.23.160.492
4njsG08Protease/0.492
1mrwK57Gag-Pol polyprotein3.4.23.160.491
1xl2189Gag-Pol polyprotein3.4.23.160.491
2hs1017Protease/0.491
3cyw017Gag-Pol polyprotein3.4.23.160.491
3d1z017Gag-Pol polyprotein3.4.23.160.491
3qbfJHGGag-Pol polyprotein3.4.23.160.491
3qrmNK7Gag-Pol polyprotein3.4.23.160.491
1d4hBEHGag-Pol polyprotein3.4.23.160.490
1qbt146Gag-Pol polyprotein3.4.23.160.490
1mesDMPGag-Pol polyprotein3.4.23.160.489
2pwcG3GGag-Pol polyprotein3.4.23.160.489
3r4b74TGag-Pol polyprotein/0.489
1kzkJE2Gag-Pol polyprotein3.4.23.160.488
2p3c3TLProtease/0.488
3qp0NI8Gag-Pol polyprotein3.4.23.160.488
1bv7XV6Gag-Pol polyprotein3.4.23.160.486
3ggu017Gag-Pol polyprotein3.4.23.160.486
3litE15Protease/0.486
1hpv478Gag-Pol polyprotein/0.485
1qbsDMPGag-Pol polyprotein3.4.23.160.485
3t3c017Gag-Pol polyprotein3.4.23.160.485
3ucb017Gag-Pol polyprotein/0.485
3bgcLJHGag-Pol polyprotein3.4.23.160.484
3el01UNGag-Pol polyprotein3.4.23.160.484
3ufnROCGag-Pol polyprotein/0.482
4a6bQG8Gag-Pol polyprotein3.4.23.160.482
9hvp0E9Gag-Pol polyprotein/0.482
1ajxAH1Gag-Pol polyprotein3.4.23.160.481
1bwb146Gag-Pol polyprotein3.4.23.160.481
1ebk0Q4Gag-Pol polyprotein3.4.23.160.481
1k6vXN2Gag-Pol polyprotein3.4.23.160.481
1odyLP1Gag-Pol polyprotein3.4.23.160.481
3nwxKVSGag-Pol polyprotein3.4.23.160.481
3nu3478Gag-Pol polyprotein3.4.23.160.480
4q1x017Gag-Pol polyprotein3.4.23.160.478
1idb0DOGag-Pol polyprotein/0.477
3qroNK9Gag-Pol polyprotein3.4.23.160.477
1merDMQGag-Pol polyprotein3.4.23.160.476
4hegG52Gag-Pol polyprotein3.4.23.160.476
1hpoUNIGag-Pol polyprotein3.4.23.160.475
3tof076Gag-Pol polyprotein2.7.7.490.475
3lixE17Protease/0.474
3qrsNK8Gag-Pol polyprotein3.4.23.160.474
4a6cQG9Gag-Pol polyprotein3.4.23.160.474
4j54G52Gag-Pol polyprotein3.4.23.160.473
1c6yMK1Protease/0.472
4i8zG08Gag-Pol polyprotein3.4.23.160.472
1hvrXK2Gag-Pol polyprotein/0.471
3lzu017Gag-Pol polyprotein3.4.23.160.471
1npvL27Gag-Pol polyprotein3.4.23.160.470
2r3tG4GGag-Pol polyprotein3.4.23.160.470
3livE16Protease/0.470
2bbbHH1Gag-Pol polyprotein3.4.23.160.468
2i0aMUIProtease/0.468
1t7j478Gag-Pol polyprotein3.4.23.160.466
3upjU03Gag-Pol polyprotein/0.466
3wsjMK1Protease/0.466
2r3wG3GGag-Pol polyprotein3.4.23.160.465
3ec0GRLGag-Pol polyprotein3.4.23.470.465
1bv9XV6Gag-Pol polyprotein3.4.23.160.463
1dmpDMQGag-Pol polyprotein3.4.23.160.460
3ecg065Gag-Pol polyprotein3.4.23.470.460
1hbvGANGag-Pol polyprotein/0.458
2r38G4GGag-Pol polyprotein3.4.23.160.458
6upjNIUGag-Pol polyprotein/0.458
3qpjN4IGag-Pol polyprotein3.4.23.160.453
3bxsDRSGag-Pol polyprotein3.4.23.160.443
1hvhQ82Gag-Pol polyprotein3.4.23.160.441
3qihNI7Gag-Pol polyprotein3.4.23.160.441