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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ees NAP 4-hydroxy-tetrahydrodipicolinate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.993
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.798
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.777
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.748
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.744
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.743
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.735
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.735
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.730
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.722
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.722
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.720
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.719
1o6z NADMalate dehydrogenase / 0.718
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.718
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.717
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.714
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.706
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.705
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.702
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.701
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.699
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.693
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.690
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.689
2x0i NAIMalate dehydrogenase / 0.688
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.688
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.685
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.685
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.684
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.683
1yqd NAPSinapyl alcohol dehydrogenase / 0.681
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.680
3tqh NDPQuinone oxidoreductase / 0.680
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.677
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.674
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.674
1pzf A3DLactate dehydrogenase / 0.673
5doz NDPJamJ / 0.671
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.670
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.670
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.668
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.664
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.664
2o4c NADErythronate-4-phosphate dehydrogenase / 0.663
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.662
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.662
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.659
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.658
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.658
3q3c NADNAD-dependent L-serine dehydrogenase / 0.658
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.657
2ejv NADL-threonine 3-dehydrogenase / 0.656
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.655
1yqx NAPSinapyl alcohol dehydrogenase / 0.655
3qwb NDPProbable quinone oxidoreductase 1.6.5.5 0.654
3x2f NAIAdenosylhomocysteinase / 0.652
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.651
2cda NAPGlucose 1-dehydrogenase / 0.651
3two NDPMannitol dehydrogenase / 0.650
4c4o NADSADH / 0.650