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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ecc NAP Dehydrofolate reductase type I

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5ecc NAPDehydrofolate reductase type I / 1.221
4kl9 NDPDihydrofolate reductase 1.5.1.3 1.087
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.999
2cig 1DGDihydrofolate reductase 1.5.1.3 0.987
3qls NDPDihydrofolate reductase 1.5.1.3 0.926
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.910
3tqa NDPDihydrofolate reductase / 0.906
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.895
1drh NAPDihydrofolate reductase 1.5.1.3 0.884
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.884
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.857
3nxx NDPDihydrofolate reductase 1.5.1.3 0.850
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.848
4m6j NDPDihydrofolate reductase 1.5.1.3 0.835
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.828
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.828
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.820
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.817
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.815
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.769
1dr2 TAPDihydrofolate reductase 1.5.1.3 0.754
2w3b NDPDihydrofolate reductase 1.5.1.3 0.753
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.751
1m78 NDPDihydrofolate reductase 1.5.1.3 0.750
3qlr NDPDihydrofolate reductase 1.5.1.3 0.749
8dfr NDPDihydrofolate reductase 1.5.1.3 0.749
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.741
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.736
3d84 NDPDihydrofolate reductase 1.5.1.3 0.719
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.715
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.711
2azn NAP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase / 0.697
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.682
4xt6 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.661
1rx6 NAPDihydrofolate reductase 1.5.1.3 0.658
1rx8 NAPDihydrofolate reductase 1.5.1.3 0.658
3dg8 NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.652