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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dx3 EST Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dx3 ESTEstrogen receptor / 1.115
3uud ESTEstrogen receptor / 1.039
4pxm ESTEstrogen receptor / 1.030
5dxg ESTEstrogen receptor / 1.027
2yja ESTEstrogen receptor / 1.009
3q95 ESLEstrogen receptor / 0.998
1gwr ESTEstrogen receptor / 0.996
2qgt EEDEstrogen receptor / 0.995
3l03 4OHEstrogen receptor / 0.989
5hyr ESTEstrogen receptor / 0.982
2yat EEUEstrogen receptor / 0.957
3oll ESTEstrogen receptor beta / 0.949
2j7x ESTEstrogen receptor beta / 0.941
2g5o DRQEstrogen receptor / 0.933
3ols ESTEstrogen receptor beta / 0.930
2b1z 17MEstrogen receptor / 0.905
4j24 ESTEstrogen receptor beta / 0.897
4j26 ESTEstrogen receptor beta / 0.887
2ocf ESTEstrogen receptor / 0.866
1g50 ESTEstrogen receptor / 0.795
2pog WSTEstrogen receptor / 0.742
2pnu ENMAndrogen receptor / 0.725
4hlw TESAndrogen receptor / 0.723
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.719
2ayr L4GEstrogen receptor / 0.715
1x7r GENEstrogen receptor / 0.704
2w8y 486Progesterone receptor / 0.701
3nbr ASDSteroid Delta-isomerase 5.3.3.1 0.699
1lhu ESTSex hormone-binding globulin / 0.697
4at2 ASDPossible succinate dehydrogenase / 0.695
1x7e 244Estrogen receptor / 0.689
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.688
3s79 ASDAromatase 1.14.14.14 0.687
2aa7 1CAMineralocorticoid receptor / 0.684
4iv4 1GSEstrogen receptor / 0.684
4iwf 15QEstrogen receptor / 0.683
4a2j AS0Progesterone receptor / 0.680
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.676
3ert OHTEstrogen receptor / 0.675
1fdt ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.673
4j6b PLOCytochrome P450 monooxygenase / 0.672
1lho AOMSex hormone-binding globulin / 0.671
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.671
4ofu DHTAndrogen receptor / 0.671
1aqu ESTEstrogen sulfotransferase, testis isoform 2.8.2.4 0.668
2aa5 STRMineralocorticoid receptor / 0.668
4e5f 0N7Polymerase acidic protein / 0.667
2piu DHTAndrogen receptor / 0.666
2ao6 R18Androgen receptor / 0.665
1err RALEstrogen receptor / 0.663
2gpu OHTEstrogen-related receptor gamma / 0.663
3m8c EQUSteroid Delta-isomerase 5.3.3.1 0.663
4jvl ESTEstrogen sulfotransferase 2.8.2.4 0.662
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
1yb1 AOIEstradiol 17-beta-dehydrogenase 11 1.1.1.62 0.658
2ovh AS0Progesterone receptor / 0.658
2qe4 JJ3Estrogen receptor / 0.658
2rlc CHDCholoylglycine hydrolase 3.5.1.24 0.657
2vdy HCYCorticosteroid-binding globulin / 0.657
1sr7 MOFProgesterone receptor / 0.655
2abi 1CAMineralocorticoid receptor / 0.653
2ovm AS0Progesterone receptor / 0.651
4ofr DHTAndrogen receptor / 0.651