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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dr6 SKE Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dr6 SKEAurora kinase A 2.7.11.1 0.930
5dr9 SKEAurora kinase A 2.7.11.1 0.899
5dt0 SKEAurora kinase A 2.7.11.1 0.878
5dpv SKEAurora kinase A 2.7.11.1 0.857
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4dea NHIAurora kinase A 2.7.11.1 0.718
3ama SKEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
3uo5 0BXAurora kinase A 2.7.11.1 0.697
3rni 21ZCyclin-dependent kinase 2 2.7.11.22 0.694
4qmu SKESerine/threonine-protein kinase 24 2.7.11.1 0.685
3lcd BDYMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.668
3k5u PFQAurora kinase A 2.7.11.1 0.667
3rk9 09ZCyclin-dependent kinase 2 2.7.11.22 0.667
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.663
2np8 CC3Aurora kinase A 2.7.11.1 0.661
3r8u Z31Cyclin-dependent kinase 2 2.7.11.22 0.661
4jia 1K3Tyrosine-protein kinase JAK2 / 0.661
2izs BRQCasein kinase I isoform gamma-3 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2j4z 626Aurora kinase A 2.7.11.1 0.659
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.655
4bbf O19Tyrosine-protein kinase JAK2 / 0.650