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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cpm FNR NADH:flavin oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cpm FNRNADH:flavin oxidoreductase / 1.390
4utk FNRXenobiotic reductase / 1.237
4uth FMNXenobiotic reductase / 1.227
4utm FNRXenobiotic reductase / 1.227
3l5l FMNXenobiotic reductase / 1.212
3n19 FNRXenobiotic reductase / 1.203
4utl FNRXenobiotic reductase / 1.184
3n14 FMNXenobiotic reductase / 1.149
2h8x FMNXenA / 1.082
4m5p FMNNADPH dehydrogenase / 1.006
1z41 FMNNADPH dehydrogenase / 1.003
1z48 FMNNADPH dehydrogenase / 1.003
1z44 FMNNADPH dehydrogenase / 0.988
3hf3 FMNChromate reductase / 0.971
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.960
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.959
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.952
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.946
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.939
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.937
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.934
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.925
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.924
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.913
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.913
3l67 FMNXenobiotic reductase / 0.904
3p84 FMNPentaerythritol tetranitrate reductase / 0.903
3p8i FMNPentaerythritol tetranitrate reductase / 0.902
1h51 FMNPentaerythritol tetranitrate reductase / 0.899
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.899
3p8j FMNPentaerythritol tetranitrate reductase / 0.899
1h63 FMNPentaerythritol tetranitrate reductase / 0.897
2abb FMNPentaerythritol tetranitrate reductase / 0.896
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.891
3f03 FMNPentaerythritol tetranitrate reductase / 0.888
1vyr FMNPentaerythritol tetranitrate reductase / 0.887
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.887
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.883
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.879
4e2d FMNDehydrogenase / 0.877
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.877
1h50 FMNPentaerythritol tetranitrate reductase / 0.872
3gr8 FMNNADPH dehydrogenase / 0.870
4jic FMNGTN Reductase / 0.868
3p67 FMNPentaerythritol tetranitrate reductase / 0.867
4yco FMNtRNA-dihydrouridine(16) synthase / 0.863
3gka FMNN-ethylmaleimide reductase / 0.855
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.853
4e2b FMNDehydrogenase / 0.852
4tmb FMNOld yellow enzyme / 0.850
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.845
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.842
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.838
3p74 FMNPentaerythritol tetranitrate reductase / 0.831
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.823
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.821
4tmc FMNOld yellow enzyme / 0.821
3p62 FMNPentaerythritol tetranitrate reductase / 0.820
1gwj FMNMorphinone reductase / 0.816
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.815
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.806
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.806
3atz FMNProstaglandin F2a synthase / 0.805
3p82 FMNPentaerythritol tetranitrate reductase / 0.804
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.797
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.793
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.793
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.787
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.786
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.784
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.783
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.779
2nli FMNLactate oxidase / 0.770
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.768
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.767
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.765
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.764
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.764
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.760
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.758
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.755
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.755
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.755
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.754
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.748
2e77 FMNLactate oxidase / 0.747
2z6i FMN2-nitropropane dioxygenase / 0.746
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.744
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.728
3aty FMNProstaglandin F2a synthase / 0.726
4qai FMNNADPH dehydrogenase / 0.724
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.722
2j6x FMNLactate oxidase / 0.713
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.707
4cw5 FMNDfnA / 0.705
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.703
4rje FNRLactate oxidase / 0.696
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.695
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.691
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.685
2d29 FADAcyl-CoA dehydrogenase / 0.682
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.681
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.681
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.680
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.679
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.679
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.678
2ohh FMNType A flavoprotein FprA 1 0.676
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.675
2hfo FMNActivator of photopigment and puc expression / 0.674
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.673
1vhn FMNtRNA-dihydrouridine synthase / 0.672
4j8p FMNFlavodoxin / 0.669
4bby FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.666
4eb4 UMPThymidylate synthase 2.1.1.45 0.666
1t5b FMNFMN-dependent NADH-azoreductase / 0.663
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.662
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.660
1iqr FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.659
1zpt FAD5,10-methylenetetrahydrofolate reductase 1.5.1.20 0.659
2gjl FMNNitronate monooxygenase 1.13.12.16 0.659
3w8w FADPutative FAD-dependent oxygenase EncM / 0.659
3oix FMNDihydroorotate dehydrogenase / 0.658
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.657
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.657
1ycf FMNNitric oxide reductase 1 0.656
4inb 1F6Gag protein / 0.655
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.653
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.652
2vp4 DCPDeoxynucleoside kinase / 0.652
1kxp ATPActin, alpha skeletal muscle / 0.651
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.650