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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cno ANP Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cno ANPEpidermal growth factor receptor 2.7.10.1 1.012
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.944
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.822
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.802
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.757
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.752
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.747
3ork AGSSerine/threonine protein kinase / 0.741
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.721
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.705
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.699
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.696
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.695
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.692
3rep ATPIntegrin-linked protein kinase 2.7.11.1 0.691
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.690
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.689
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.687
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.683
3sl2 ATPSensor histidine kinase WalK / 0.673
3akl ANPSerine/threonine-protein kinase CtkA 2.7.11.1 0.672
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2olc ADPMethylthioribose kinase 2.7.1.100 0.671
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.669
3b2t M33Fibroblast growth factor receptor 2 / 0.665
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.663
1ir3 ANPInsulin receptor 2.7.10.1 0.662
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.662
3cly ACPFibroblast growth factor receptor 2 / 0.660
4wud ANPDNA gyrase subunit B / 0.660
3bu5 ATPInsulin receptor 2.7.10.1 0.658
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.657
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.657
5eg3 ACPFibroblast growth factor receptor 2 / 0.656
1ol6 ATPAurora kinase A 2.7.11.1 0.655
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.655
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.655
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.655
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.655
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.654
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.654
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.653
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4xhg ADPUncharacterized protein / 0.652
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.651
2c2a ADPSensor histidine kinase / 0.651
4o0u ADNAurora kinase A 2.7.11.1 0.651
4wzy ATPMaltokinase 2.7.1.175 0.651
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.650
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.650
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.650
5ccy TMPPolymerase acidic protein / 0.650
5d4g U5PPolymerase acidic protein / 0.650