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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ckw ANP Uncharacterized protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5ckw ANPUncharacterized protein / 1.025
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.743
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.741
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.721
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.702
2zdg ADPD-alanine--D-alanine ligase / 0.698
4cvm ANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.691
1ol6 ATPAurora kinase A 2.7.11.1 0.690
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.681
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.679
4ffl ADPUncharacterized protein / 0.679
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.679
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.679
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.677
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.677
5ce3 ADPProtein kinase YopO / 0.676
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
5dos ATPAurora kinase A 2.7.11.1 0.675
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.674
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.673
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.671
4ysj ADPCalmodulin-like domain protein kinase / 0.670
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.669
3lfz ADPUncharacterized protein MJ1225 / 0.669
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.668
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.667
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
5dt4 ATPAurora kinase A 2.7.11.1 0.666
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.665
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.665
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.664
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.664
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.663
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.663
4wzy ATPMaltokinase 2.7.1.175 0.663
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.661
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.661
5la6 ACPTubulin tyrosine ligase / 0.660
3c4z ADPRhodopsin kinase / 0.659
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.659
3ba6 AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.657
2olc ADPMethylthioribose kinase 2.7.1.100 0.656
3a5z KAAElongation factor P--(R)-beta-lysine ligase / 0.656
5dr2 ATPAurora kinase A 2.7.11.1 0.656
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.655
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.654
2pui ADPMethylthioribose kinase 2.7.1.100 0.653
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.653
1ztf XYARIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.652
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.651
2pyw ADPMethylthioribose kinase 2.7.1.100 0.651
4fu0 ADPD-alanine--D-alanine ligase / 0.651
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.651
1loo GTPAdenylosuccinate synthetase isozyme 1 / 0.650
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.650