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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4zvn FAD Ribosyldihydronicotinamide dehydrogenase [quinone]

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.412
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.285
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.264
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.234
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.210
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.111
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 1.065
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.041
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.007
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.985
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.984
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.976
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.974
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.956
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.941
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.937
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.919
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.908
4gi5 FADPutative NAD(P)H dehydrogenase (Quinone) / 0.858
2b3d FADModulator of drug activity B / 0.822
4j8p FMNFlavodoxin / 0.802
3klb FMNUncharacterized protein / 0.793
3rpe FADPutative modulator of drug activity / 0.780
4n9q FMNFMN-dependent NADH-azoreductase 1 / 0.779
3lcm FADPutative oxidoreductase / 0.765
2ohj FMNType A flavoprotein FprA 1 0.758
2hpv FMNFMN-dependent NADH-azoreductase 1.7 0.755
3w77 FMNFMN-dependent NADH-azoreductase / 0.740
2q9u FMNA-type flavoprotein / 0.732
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.731
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.709
1vhn FMNtRNA-dihydrouridine synthase / 0.703
4hs4 FMNChromate reductase / 0.698
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.695
4r81 FMNPredicted NADH dehydrogenase / 0.692
3qfr FMNNADPH--cytochrome P450 reductase / 0.690
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.689
3aty FMNProstaglandin F2a synthase / 0.689
3eo8 FMNPutative nitroreductase / 0.688
4uth FMNXenobiotic reductase / 0.688
2ohh FMNType A flavoprotein FprA 1 0.687
1t5b FMNFMN-dependent NADH-azoreductase / 0.686
4ttc FMNIodotyrosine deiodinase 1 / 0.682
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.681
2dvl FADAcyl-CoA dehydrogenase / 0.678
3f03 FMNPentaerythritol tetranitrate reductase / 0.678
3l5l FMNXenobiotic reductase / 0.676
4qly FMNEnone reductase CLA-ER / 0.676
4utm FNRXenobiotic reductase / 0.675
1akr FMNFlavodoxin / 0.674
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.674
1gwj FMNMorphinone reductase / 0.672
2v5u FMNFlavodoxin / 0.671
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.668
3l67 FMNXenobiotic reductase / 0.668
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.667
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.666
3p8j FMNPentaerythritol tetranitrate reductase / 0.666
4dy4 FMNNAD(P)H dehydrogenase (quinone) / 0.666
3zho FMNNAD(P)H dehydrogenase (quinone) / 0.665
4n82 FMNRibonucleotide reductase (NrdI family protein), putative / 0.665
1h63 FMNPentaerythritol tetranitrate reductase / 0.663
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.663
4cw5 FMNDfnA / 0.663
2ohi FMNType A flavoprotein FprA 1 0.662
4y9l FADAcyl-CoA dehydrogenase family member 11 / 0.662
4qai FMNNADPH dehydrogenase / 0.661
5jsc FADPutative acyl-CoA dehydrogenase / 0.661
3esz FMNFlavodoxin / 0.659
4bmo FMNProtein NrdI / 0.659
3atz FMNProstaglandin F2a synthase / 0.657
4tmb FMNOld yellow enzyme / 0.657
1czn FMNFlavodoxin / 0.655
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 0.655
5f12 FMNNAD(P)H dehydrogenase (quinone) / 0.655
1t0i FMNNAD(P)H-dependent FMN reductase LOT6 / 0.653
1ofv FMNFlavodoxin / 0.652
2zbw FADFerredoxin--NADP reductase / 0.652
4hia FMNLOV protein / 0.652
3sf6 FDAGlutaryl-CoA dehydrogenase / 0.651
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.650
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.650