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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xj4 3AT Cyclic GMP-AMP synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xj4 3ATCyclic GMP-AMP synthase / 0.946
4xj3 GTPCyclic GMP-AMP synthase / 0.881
4u03 GTPCyclic GMP-AMP synthase / 0.856
4u0m GTPCyclic GMP-AMP synthase / 0.816
2q66 ATPPoly(A) polymerase 2.7.7.19 0.798
3hiy UTPUncharacterized protein / 0.789
2b51 UTPRNA editing complex protein MP57 / 0.783
4rwn APC2'-5'-oligoadenylate synthase 1 2.7.7.84 0.766
4dfk 0L5DNA polymerase I, thermostable 2.7.7.7 0.747
1r8b ATPCCA-adding enzyme 2.7.7.72 0.743
4dtp DGTDNA-directed DNA polymerase / 0.741
4k97 ATPCyclic GMP-AMP synthase / 0.731
4dtj TTPDNA-directed DNA polymerase / 0.726
2ikf UTPPoly(A) polymerase, putative / 0.725
3lzj CTPDNA-directed DNA polymerase / 0.725
4fjh DGTDNA-directed DNA polymerase / 0.725
3ne6 DCPDNA-directed DNA polymerase / 0.723
4fj5 DTPDNA-directed DNA polymerase / 0.719
3g6x DGTDNA polymerase iota 2.7.7.7 0.716
3er9 3ATPoly(A) polymerase catalytic subunit 2.7.7.19 0.713
4ptf DCPDNA polymerase epsilon catalytic subunit A 2.7.7.7 0.713
4txz G2PCyclic GMP-AMP synthase / 0.710
4fk4 DGTDNA-directed DNA polymerase / 0.708
4fjj TTPDNA-directed DNA polymerase / 0.705
1qsy DDSDNA polymerase I, thermostable 2.7.7.7 0.699
4fvq ATPTyrosine-protein kinase JAK2 / 0.697
3q23 G2PVirion DNA-directed RNA polymerase / 0.696
4fhp UTPTerminal uridylyltransferase cid1 / 0.696
2b56 UTPRNA editing complex protein MP57 / 0.694
4fjl DGTDNA-directed DNA polymerase / 0.693
4fjm DCPDNA-directed DNA polymerase / 0.693
4df8 0L4DNA polymerase I, thermostable 2.7.7.7 0.689
2q0c CTPPoly(A) polymerase, putative / 0.687
4m3t ATPDNA-directed DNA polymerase / 0.683
4m42 ATPDNA-directed DNA polymerase / 0.683
3au2 DGTDNA polymerase beta family (X family) / 0.682
4lt6 3ATPoly(A) polymerase gamma 2.7.7.19 0.679
4df4 0L3DNA polymerase I, thermostable 2.7.7.7 0.676
3sup DCPDNA-directed DNA polymerase / 0.675
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.674
4yvz 3ATDNA integrity scanning protein DisA / 0.674
4m3x ATPDNA-directed DNA polymerase / 0.673
4fvr ATPTyrosine-protein kinase JAK2 / 0.672
1r89 CTPCCA-adding enzyme 2.7.7.72 0.671
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.671
1fa0 3ATPoly(A) polymerase 2.7.7.19 0.667
4dtx TTPDNA-directed DNA polymerase / 0.666
4xul GTPUncharacterized protein mg662 / 0.666
2q0d ATPPoly(A) polymerase, putative / 0.664
4jsy GTPMetallophosphoesterase / 0.661
4fhy 3ATTerminal uridylyltransferase cid1 / 0.660
3wbz ATPtRNA(His) guanylyltransferase {ECO:0000256|PIRNR:PIRNR028980} / 0.659
1qtm TTPDNA polymerase I, thermostable 2.7.7.7 0.658
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.655
4kln AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.655
5i4n ATPTyrosine-protein kinase JAK2 / 0.655
1r8c UTPCCA-adding enzyme 2.7.7.72 0.654
4at8 ATPInterleukin enhancer-binding factor 2 / 0.654
1cjv DADAdenylate cyclase type 2 / 0.653
1cjv DADAdenylate cyclase type 5 / 0.653
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.653
4khy TTPDNA-directed DNA polymerase / 0.652
2q0f UTPPoly(A) polymerase, putative / 0.651
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.650