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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tkg 09L Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4tkg 09LTankyrase-2 2.4.2.30 1.077
3u9y 09LTankyrase-2 2.4.2.30 0.919
4tjy 3GNTankyrase-2 2.4.2.30 0.732
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.724
4avu LDRTankyrase-2 2.4.2.30 0.714
4tvj 09LPoly [ADP-ribose] polymerase 2 2.4.2.30 0.711
4li8 1XQTankyrase-1 2.4.2.30 0.704
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.690
4j21 AJ6Tankyrase-2 2.4.2.30 0.690
4j22 AJ7Tankyrase-2 2.4.2.30 0.688
4but 31FTankyrase-2 2.4.2.30 0.686
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.685
3kr8 XAVTankyrase-2 2.4.2.30 0.683
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.682
4bui W2ETankyrase-2 2.4.2.30 0.672
4buw F33Tankyrase-2 2.4.2.30 0.672
4bux F35Tankyrase-2 2.4.2.30 0.671
4bus 32FTankyrase-2 2.4.2.30 0.670
4buv 16ITankyrase-2 2.4.2.30 0.670
4gv0 8MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.670
4bue JQFTankyrase-2 2.4.2.30 0.669
4buu F38Tankyrase-2 2.4.2.30 0.668
4i9i 1DYTankyrase-1 2.4.2.30 0.668
4buf F36Tankyrase-2 2.4.2.30 0.667
4avw G18Tankyrase-2 2.4.2.30 0.665
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.665
4hki FLNTankyrase-2 2.4.2.30 0.665
4msg 2C6Tankyrase-1 2.4.2.30 0.661
4mt9 2D6Tankyrase-1 2.4.2.30 0.660
4l32 1VFTankyrase-2 2.4.2.30 0.659
2rcw AAIPoly [ADP-ribose] polymerase 1 2.4.2.30 0.657
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.657
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.657
4hlf 15ZTankyrase-2 2.4.2.30 0.655
4bud 29FTankyrase-2 2.4.2.30 0.651