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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4rvu NDP Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 1.474
3jyn NDPQuinone oxidoreductase / 1.120
1qor NDPQuinone oxidoreductase 1 / 0.994
2y05 NAPProstaglandin reductase 1 / 0.843
3qwb NDPProbable quinone oxidoreductase 1.6.5.5 0.843
2oby NAPQuinone oxidoreductase PIG3 1 0.839
4b7x NAPProbable oxidoreductase / 0.820
2c0c NAPProstaglandin reductase 3 1 0.795
2j8z NAPQuinone oxidoreductase PIG3 1 0.777
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.772
5doz NDPJamJ / 0.758
5dp2 NAPCurF / 0.756
3slk NDPPolyketide synthase extender module 2 / 0.755
1yqd NAPSinapyl alcohol dehydrogenase / 0.746
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.740
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.738
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.722
3tqh NDPQuinone oxidoreductase / 0.716
2vna NAPProstaglandin reductase 2 1.3.1.48 0.714
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.712
2o4c NADErythronate-4-phosphate dehydrogenase / 0.709
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.706
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.701
1yqx NAPSinapyl alcohol dehydrogenase / 0.700
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.699
1x7d NADPutative ornithine cyclodeaminase / 0.699
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.698
3wle NAD(R)-specific carbonyl reductase / 0.698
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.697
1guf NDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial 1.3.1.10 0.696
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.694
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.692
3abi NADUncharacterized protein / 0.690
3nx4 NAPPutative oxidoreductase / 0.689
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.686
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.683
2cdc NAPGlucose 1-dehydrogenase / 0.683
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.682
2p5y NADUDP-glucose 4-epimerase / 0.682
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.679
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.677
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.675
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.675
2gcg NDPGlyoxylate reductase/hydroxypyruvate reductase 1.1.1.79 0.673
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.673
4j43 NADUncharacterized protein / 0.672
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.671
3oet NADErythronate-4-phosphate dehydrogenase / 0.671
4xqc NADHomospermidine synthase 2.5.1.44 0.671
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.670
4j49 NADUncharacterized protein / 0.670
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.668
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.666
2x0r NADMalate dehydrogenase / 0.666
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.666
4jk3 NADUncharacterized protein / 0.665
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.664
4cpd NADAlcohol dehydrogenase / 0.663
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.661
4yp5 NAPNicotinamide-nucleotide adenylyltransferase 2.7.7.1 0.661
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.660
1i36 NAPConserved protein / 0.659
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.659
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.659
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.659
4tvb NADHomospermidine synthase 2.5.1.44 0.659
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.658
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.657
3mje NDPAmphB / 0.657
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.657
1uxk NADMalate dehydrogenase / 0.656
2c29 NAPDihydroflavonol 4-reductase / 0.656
2jah NDPClavaldehyde dehydrogenase / 0.656
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.656
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.655
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.655
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.655
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.655
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.654
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.653
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.652
1d4o NAPNAD(P) transhydrogenase, mitochondrial / 0.652
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.652
1wnt NAPL-xylulose reductase 1.1.1.10 0.652
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.652
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.652
3two NDPMannitol dehydrogenase / 0.651
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.651
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
4y1b NAPAntE / 0.651
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.650
4j49 NAIUncharacterized protein / 0.650