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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pxz CLR P2Y purinoceptor 12

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4pxz CLRP2Y purinoceptor 12 / 1.385
4py0 6ATP2Y purinoceptor 12 / 0.917
1zh8 NAPUncharacterized protein / 0.721
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.698
5a05 NDPGlucose-fructose oxidoreductase / 0.692
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.690
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.682
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.681
3qtt ANPPantothenate synthetase / 0.680
5a06 NDPGlucose-fructose oxidoreductase / 0.680
4i9b NADPutative betaine aldehyde dehyrogenase / 0.679
1mwm ADPPlasmid segregation protein ParM / 0.677
3q2k NAIProbable oxidoreductase / 0.674
5a04 NDPGlucose-fructose oxidoreductase / 0.674
5bsg NAPPyrroline-5-carboxylate reductase / 0.674
1yon A2R2-dehydropantoate 2-reductase 1.1.1.169 0.671
1qz5 ATPActin, alpha skeletal muscle / 0.665
4xgi NADGlutamate dehydrogenase / 0.662
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.660
2vp0 TTPDeoxynucleoside kinase / 0.659
3i6q NDPPutative leucoanthocyanidin reductase 1 / 0.659
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.659
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.657
2bbw GP5Adenylate kinase 4, mitochondrial / 0.656
4eht ADP2-hydroxyisocaproyl-CoA dehydratase activator / 0.656
2vp4 DCPDeoxynucleoside kinase / 0.655
2whx ADPGenome polyprotein 3.4.21.91 0.655
1wua ATPActin, alpha skeletal muscle / 0.654
2jcs TTPDeoxynucleoside kinase / 0.654
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.654
4k41 ATPActin, alpha skeletal muscle / 0.654
1s22 ATPActin, alpha skeletal muscle / 0.653
1h65 GDPTranslocase of chloroplast 34 3.6.5 0.652
1t2a GDPGDP-mannose 4,6 dehydratase 4.2.1.47 0.651
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.650
5a02 NAPGlucose-fructose oxidoreductase / 0.650