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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4om8 NAD 3-hydroxybutyryl-coA dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.985
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.835
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.831
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.804
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.802
3f3s NADLambda-crystallin homolog / 0.772
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.758
4kug NAD3-hydroxybutyryl-CoA dehydrogenase / 0.752
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.736
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.735
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.729
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.726
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.726
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.718
3q2k NAIProbable oxidoreductase / 0.718
3keq NADRedox-sensing transcriptional repressor Rex / 0.715
3q3c NADNAD-dependent L-serine dehydrogenase / 0.710
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.709
2f1k NAPPrephenate dehydrogenase / 0.707
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.706
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.706
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.705
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.703
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.702
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.702
4k28 NADShikimate dehydrogenase family protein / 0.701
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.700
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.698
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.697
1nbo NADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.696
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.696
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.695
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.695
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.693
3hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.693
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.693
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.692
4dyd NADDiketoreductase / 0.692
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.687
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.686
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.686
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.685
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.685
1c1d NAIPhenylalanine dehydrogenase / 0.684
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.684
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.684
3ggp NADPrephenate dehydrogenase / 0.683
3dbv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.682
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.681
4j49 NAIUncharacterized protein / 0.681
3adp NAILambda-crystallin 1.1.1.45 0.678
1nqo NADGlyceraldehyde-3-phosphate dehydrogenase / 0.677
2vhx NADAlanine dehydrogenase 1.4.1.1 0.677
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.675
5a02 NAPGlucose-fructose oxidoreductase / 0.674
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.673
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.673
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.673
2voj NADAlanine dehydrogenase 1.4.1.1 0.672
3ket NADRedox-sensing transcriptional repressor Rex / 0.672
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.671
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.671
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.671
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.671
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.670
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.670
1zh8 NAPUncharacterized protein / 0.670
2czc NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.59 0.670
3keo NADRedox-sensing transcriptional repressor Rex / 0.670
3oet NADErythronate-4-phosphate dehydrogenase / 0.669
1uxk NADMalate dehydrogenase / 0.667
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.666
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.666
4j49 NADUncharacterized protein / 0.666
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.665
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.665
5a04 NDPGlucose-fructose oxidoreductase / 0.665
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.664
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.664
4c4o NADSADH / 0.664
1gyp NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.663
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.663
1rm3 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.663
2dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.663
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.662
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.660
2jd1 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.660
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.660
2yyy NAPGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.59 0.659
3ojl NADCap5O / 0.659
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.659
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.658
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.658
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.658
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.657
1jn0 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.655
1a7k NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.654
4j43 NADUncharacterized protein / 0.654
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.653
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.653
3ggg NADPrephenate dehydrogenase / 0.653
3abi NADUncharacterized protein / 0.651
3gvi ADPMalate dehydrogenase / 0.651
1dbv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.650