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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mvf STU Calcium-dependent protein kinase 2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 1.007
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.773
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.772
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.771
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.769
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.768
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.761
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.761
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.753
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.742
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.739
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.737
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.727
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.725
1byg STUTyrosine-protein kinase CSK / 0.720
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.717
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.714
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.707
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.704
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.701
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.690
1xjd STUProtein kinase C theta type 2.7.11.13 0.678
2z2w 770Wee1-like protein kinase 2.7.10.2 0.677
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.677
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
3cr0 809Wee1-like protein kinase 2.7.10.2 0.668
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.668
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.667
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.664
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.663
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.663
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.660
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.656
2vd5 BI8Myotonin-protein kinase 2.7.11.1 0.654
2etk HFSRho-associated protein kinase 1 2.7.11.1 0.651