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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mp7 PFT [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mp7 PFT[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.908
4mpc PV2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.882
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.875
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.864
4mp2 PV1[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.780
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3k98 1RCHeat shock protein HSP 90-alpha / 0.738
3k97 4CDHeat shock protein HSP 90-alpha / 0.713
2xab VHDHeat shock protein HSP 90-alpha / 0.708
3ekr PY9Heat shock protein HSP 90-alpha / 0.705
4egk RDCHeat shock protein HSP 90-alpha / 0.703
3k99 PFTHeat shock protein HSP 90-alpha / 0.692
2yjw YJWHeat shock protein HSP 90-alpha / 0.687
4efu EFUHeat shock protein HSP 90-alpha / 0.687
2yi6 6QMHeat shock protein HSP 90-alpha / 0.683
4e5l DBHPolymerase acidic protein / 0.675
3inw JZBHeat shock protein HSP 90-alpha / 0.670
2zdx P4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.665
1qy8 RDIEndoplasmin / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2yi7 BZ8Heat shock protein HSP 90-alpha / 0.659
2uwd 2GGHeat shock protein HSP 90-alpha / 0.657
1yc1 4BCHeat shock protein HSP 90-alpha / 0.655
2ccu 2D9Heat shock protein HSP 90-alpha / 0.652