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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lx9 ACO N-alpha-acetyltransferase 2.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4lx9 ACON-alpha-acetyltransferase 2.3.1 1.448
2x7b COAN-alpha-acetyltransferase 2.3.1 1.138
4r3k COAN-alpha-acetyltransferase 2.3.1 1.092
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.977
2cns ACORibosomal-protein-alanine acetyltransferase / 0.903
4kub COAUncharacterized protein / 0.872
3pgp ACOUncharacterized protein / 0.869
2r8v ACOAmino-acid acetyltransferase / 0.862
5kgj ACOPredicted acetyltransferase / 0.856
2cnt COARibosomal-protein-alanine acetyltransferase / 0.846
5kf9 ACOPredicted acetyltransferase / 0.846
5kf2 ACOPredicted acetyltransferase / 0.839
5kf8 ACOPredicted acetyltransferase / 0.837
5kgp ACOPredicted acetyltransferase / 0.835
3mgd ACOPredicted acetyltransferase / 0.818
3te4 ACODopamine N-acetyltransferase / 0.809
1wwz ACOUncharacterized protein / 0.804
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.798
2bsw CAOProbable acetyltransferase / 0.797
2jdc CAOProbable acetyltransferase / 0.796
5kf1 ACOPredicted acetyltransferase / 0.796
2rc4 ACOHistone acetyltransferase KAT6A / 0.788
1ghe ACOAcetyltransferase 2.3.1 0.785
2jdd ACOProbable acetyltransferase / 0.780
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.779
5c88 COAN-alpha-acetyltransferase / 0.778
2a4n COAAac(6')-Ii protein / 0.777
3r1k COAN-acetyltransferase Eis / 0.777
1cjw COTSerotonin N-acetyltransferase / 0.775
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.773
4jwp ACOGCN5-related N-acetyltransferase / 0.773
1qsm ACOHistone acetyltransferase HPA2 / 0.765
1kuv CA5Serotonin N-acetyltransferase / 0.764
2zw4 COABleomycin acetyltransferase / 0.757
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.755
1j4j ACOAcetyltransferase 2.3.1 0.753
4cry ACOPanD regulatory factor / 0.753
1pu9 COAHAT A1 / 0.751
5kgh ACOPredicted acetyltransferase / 0.751
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.746
3k9u ACOSpermidine N(1)-acetyltransferase / 0.745
2y0m ACOHistone acetyltransferase KAT8 / 0.740
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.738
2zw5 COABleomycin acetyltransferase / 0.738
3f8k COAUncharacterized protein / 0.736
1n71 COAAac(6')-Ii protein / 0.734
3d2m COAAmino-acid acetyltransferase / 0.734
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.731
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.730
2cy2 ACOProbable acetyltransferase / 0.727
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.727
2ou2 ACOHistone acetyltransferase KAT5 / 0.726
1qsr ACOHAT A1 / 0.723
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.723
3sxn COAN-acetyltransferase Eis / 0.723
1qsn COAHAT A1 / 0.722
1b87 ACOAac(6')-Ii protein / 0.721
1fy7 COAHistone acetyltransferase ESA1 / 0.721
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.721
4kvm SER_ALA_SER_GLU_1XEN-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.720
1m1d LYXHAT A1 / 0.717
1mj9 COAHistone acetyltransferase ESA1 / 0.717
1l0c COTSerotonin N-acetyltransferase / 0.716
1mja COAHistone acetyltransferase ESA1 / 0.716
1bob ACOHistone acetyltransferase type B catalytic subunit / 0.715
1mjb ACOHistone acetyltransferase ESA1 / 0.715
1pua COAHAT A1 / 0.715
5kf8 COAPredicted acetyltransferase / 0.714
1s60 COAAminoglycoside N(6')-acetyltransferase type 1 / 0.711
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.710
2vbq BSJAminoglycoside N(6')-acetyltransferase type 1 / 0.708
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.705
2ge3 ACOProbable acetyltransferase / 0.702
1ib1 COTSerotonin N-acetyltransferase / 0.701
2ozu ACOHistone acetyltransferase KAT6A / 0.696
3exn ACOProbable acetyltransferase / 0.696
4ri1 ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase 2.3.1.202 0.696
3cz7 ACOHistone acetyltransferase RTT109 2.3.1.48 0.695
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.694
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.692
4h6u ACOAlpha-tubulin N-acetyltransferase 1 / 0.691
3d2p COAAmino-acid acetyltransferase / 0.689
3r96 ACOMccE protein / 0.689
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.688
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.687
4qvt ACOAcetyltransferase YpeA 2.3.1 0.687
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.687
1kuy COTSerotonin N-acetyltransferase / 0.682
3q33 ACOHistone acetyltransferase RTT109 2.3.1.48 0.682
4u9z COAAlpha-tubulin N-acetyltransferase 1 / 0.680
5kf2 COAPredicted acetyltransferase / 0.680
2ft0 ACOdTDP-fucosamine acetyltransferase / 0.675
4mxe ACON-acetyltransferase ESCO1 2.3.1 0.674
2ob0 ACON-alpha-acetyltransferase 50 / 0.673
3r95 ACOMccE protein / 0.672
4b5o ACOAlpha-tubulin N-acetyltransferase 1 / 0.672
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.671
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.670
1bo4 COAAminoglycoside-(3)-N-acetyltransferase / 0.669
2giv ACOHistone acetyltransferase KAT8 / 0.669
3dr8 ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase / 0.669
2psw COAN-alpha-acetyltransferase 50 / 0.664
2vqy ACOAAC(6')-Ib / 0.661
3vwd ACOAlpha-tubulin N-acetyltransferase 1 / 0.655
2bue COAAAC(6')-Ib / 0.650
2qir COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.650