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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4k9h 1QU Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4k9h 1QUBeta-secretase 1 3.4.23.46 1.142
2wf0 ZY0Beta-secretase 1 3.4.23.46 1.004
2vj7 VG6Beta-secretase 1 3.4.23.46 1.002
2vnn CM7Beta-secretase 1 3.4.23.46 0.956
2vnm CM8Beta-secretase 1 3.4.23.46 0.949
2viz VG4Beta-secretase 1 3.4.23.46 0.939
3k5g BJCBeta-secretase 1 3.4.23.46 0.923
2wez ZYEBeta-secretase 1 3.4.23.46 0.918
2vj6 VG5Beta-secretase 1 3.4.23.46 0.914
2xfj VG5Beta-secretase 1 3.4.23.46 0.913
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.898
2viy VG3Beta-secretase 1 3.4.23.46 0.896
2xfk AA9Beta-secretase 1 3.4.23.46 0.896
3veu 0GOBeta-secretase 1 3.4.23.46 0.895
3dv5 BAVBeta-secretase 1 3.4.23.46 0.880
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.873
2xfi XFIBeta-secretase 1 3.4.23.46 0.872
2wf2 ZY2Beta-secretase 1 3.4.23.46 0.871
2vj9 VG7Beta-secretase 1 3.4.23.46 0.865
4dpf 0LGBeta-secretase 1 3.4.23.46 0.860
2vij C44Beta-secretase 1 3.4.23.46 0.850
4fco 0U4Beta-secretase 1 3.4.23.46 0.841
2iqg F2IBeta-secretase 1 3.4.23.46 0.839
3ohf 3HFBeta-secretase 1 3.4.23.46 0.839
4dpi 0N1Beta-secretase 1 3.4.23.46 0.838
2b8v 3BNBeta-secretase 1 3.4.23.46 0.832
2b8l 5HABeta-secretase 1 3.4.23.46 0.829
2p8h MY9Beta-secretase 1 3.4.23.46 0.826
3cib 314Beta-secretase 1 3.4.23.46 0.821
3lpj Z75Beta-secretase 1 3.4.23.46 0.821
1w51 L01Beta-secretase 1 3.4.23.46 0.820
2hiz LIJBeta-secretase 1 3.4.23.46 0.815
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.815
3lpi Z74Beta-secretase 1 3.4.23.46 0.813
3k5c 0BIBeta-secretase 1 3.4.23.46 0.810
3ohh 3HHBeta-secretase 1 3.4.23.46 0.806
2hm1 LIQBeta-secretase 1 3.4.23.46 0.804
3cic 316Beta-secretase 1 3.4.23.46 0.802
3pi5 3P5Beta-secretase 1 3.4.23.46 0.798
2p83 MR0Beta-secretase 1 3.4.23.46 0.792
2vkm BSDBeta-secretase 1 3.4.23.46 0.792
3pww ROCEndothiapepsin 3.4.23.22 0.790
4lxm 1YUBeta-secretase 1 3.4.23.46 0.789
2vie VG0Beta-secretase 1 3.4.23.46 0.787
3qbh QBHBeta-secretase 1 3.4.23.46 0.787
4ke0 1R8Beta-secretase 1 3.4.23.46 0.780
4i0h 1BLBeta-secretase 1 3.4.23.46 0.776
2qzl IXSBeta-secretase 1 3.4.23.46 0.771
3r2f PB0Beta-secretase 1 3.4.23.46 0.767
3lpk Z76Beta-secretase 1 3.4.23.46 0.763
3nsh 957Beta-secretase 1 3.4.23.46 0.758
4i0i 957Beta-secretase 1 3.4.23.46 0.758
4gid 0GHBeta-secretase 1 3.4.23.46 0.757
4lxa 1YSBeta-secretase 1 3.4.23.46 0.757
3vf3 0GSBeta-secretase 1 3.4.23.46 0.756
3cid 318Beta-secretase 1 3.4.23.46 0.752
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3tpr 5HABeta-secretase 1 3.4.23.46 0.741
2fdp FRPBeta-secretase 1 3.4.23.46 0.740
3vg1 0GTBeta-secretase 1 3.4.23.46 0.735
4exg 916Beta-secretase 1 3.4.23.46 0.729
4lxk 1YTBeta-secretase 1 3.4.23.46 0.724
3i25 MV7Beta-secretase 1 3.4.23.46 0.722
4ewo 996Beta-secretase 1 3.4.23.46 0.713
3dm6 757Beta-secretase 1 3.4.23.46 0.707
3k5f AYHBeta-secretase 1 3.4.23.46 0.705
3dv1 AR9Beta-secretase 1 3.4.23.46 0.698
3skg PB8Beta-secretase 1 3.4.23.46 0.690
1rne C60Renin 3.4.23.15 0.687
4d89 BXDBeta-secretase 1 3.4.23.46 0.685
1e80 0GQEndothiapepsin 3.4.23.22 0.684
3n4l 842Beta-secretase 1 3.4.23.46 0.684
2jjj 0QSEndothiapepsin 3.4.23.22 0.683
2f3e AXQBeta-secretase 1 3.4.23.46 0.678
1gvv 0GMEndothiapepsin 3.4.23.22 0.676
4i0j 842Beta-secretase 1 3.4.23.46 0.676
4ke1 1R6Beta-secretase 1 3.4.23.46 0.672
2p4j 23IBeta-secretase 1 3.4.23.46 0.670
3ixj 586Beta-secretase 1 3.4.23.46 0.669
2f3f AXFBeta-secretase 1 3.4.23.46 0.664
1od1 0QSEndothiapepsin 3.4.23.22 0.663
4dh6 0KNBeta-secretase 1 3.4.23.46 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3qi1 C6ABeta-secretase 1 3.4.23.46 0.659
2g94 ZPQBeta-secretase 1 3.4.23.46 0.658
4k8s 1QTBeta-secretase 1 3.4.23.46 0.657
2oah QINBeta-secretase 1 3.4.23.46 0.650