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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j53 1J4 Serine/threonine-protein kinase PLK1 2.7.11.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.972
4j52 1J3Serine/threonine-protein kinase PLK1 2.7.11.21 0.858
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.835
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3uo5 0BXAurora kinase A 2.7.11.1 0.693
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.687
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.686
2vgp AD6Aurora kinase B-A 2.7.11.1 0.674
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.665
4dea NHIAurora kinase A 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.653
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.651
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.651