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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ix5 ANP Uncharacterized protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ix5 ANPUncharacterized protein / 0.925
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.744
4ix6 ADPUncharacterized protein / 0.738
2pyw ADPMethylthioribose kinase 2.7.1.100 0.731
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.726
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.717
4dee ADPAurora kinase A 2.7.11.1 0.712
3c50 ADPRhodopsin kinase / 0.705
4wh3 ATPN-acetylhexosamine 1-kinase 2.7.1.162 0.705
4ysj ADPCalmodulin-like domain protein kinase / 0.699
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.697
1mq4 ADPAurora kinase A 2.7.11.1 0.695
4ix4 ADPUncharacterized protein / 0.694
3cly ACPFibroblast growth factor receptor 2 / 0.693
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.693
3c4z ADPRhodopsin kinase / 0.692
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.690
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.688
5dt3 ATPAurora kinase A 2.7.11.1 0.686
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.685
4utd ACPAurora kinase A 2.7.11.1 0.685
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.683
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.683
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.683
3bu5 ATPInsulin receptor 2.7.10.1 0.682
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.682
5ce3 ADPProtein kinase YopO / 0.682
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.679
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.679
4ffr ATPUncharacterized protein / 0.679
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.679
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.678
5dos ATPAurora kinase A 2.7.11.1 0.676
1m0w ANPGlutathione synthetase 6.3.2.3 0.675
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.675
5dt4 ATPAurora kinase A 2.7.11.1 0.675
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.674
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.673
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.673
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.669
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.666
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.666
5dnr ATPAurora kinase A 2.7.11.1 0.666
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.665
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.665
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.663
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.662
3q5i ANPProtein kinase, putative / 0.661
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.660
4ylh YE1(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase / 0.660
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.659
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.659
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.658
3qc9 ADPRhodopsin kinase / 0.658
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.658
2pui ADPMethylthioribose kinase 2.7.1.100 0.657
2pup ADPMethylthioribose kinase 2.7.1.100 0.657
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.656
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.656
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.656
4q5h ANPProtein kinase OspG 2.7 0.656
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.655
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.655
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
5dr2 ATPAurora kinase A 2.7.11.1 0.655
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.654
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.654
1ztf XYARIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.653
4ceg ADPAurora kinase A 2.7.11.1 0.653
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.652
4fu0 ADPD-alanine--D-alanine ligase / 0.651
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.650
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.650
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.650