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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i23 1C9 Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.921
2itz IREEpidermal growth factor receptor 2.7.10.1 0.787
2vwu 7X1Ephrin type-B receptor 4 2.7.10.1 0.755
3w33 W19Epidermal growth factor receptor 2.7.10.1 0.753
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
3f5p 741Insulin-like growth factor 1 receptor 2.7.10.1 0.738
4jr3 KJREpidermal growth factor receptor 2.7.10.1 0.702
3ue4 DB8Tyrosine-protein kinase ABL1 2.7.10.2 0.699
4jrv KJVEpidermal growth factor receptor 2.7.10.1 0.694
4hjo AQ4Epidermal growth factor receptor 2.7.10.1 0.692
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.678
4jq7 KJQEpidermal growth factor receptor 2.7.10.1 0.677
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.672
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.672
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.670
2vwx 7X4Ephrin type-B receptor 4 2.7.10.1 0.664
4qmx H8HSerine/threonine-protein kinase 24 2.7.11.1 0.663
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2gfs PQBMitogen-activated protein kinase 14 / 0.659
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.658
2vx0 7X7Ephrin type-B receptor 4 2.7.10.1 0.657
1di9 MSQMitogen-activated protein kinase 14 / 0.651