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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hlf 15Z Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hlf 15ZTankyrase-2 2.4.2.30 0.924
4hlg 20BTankyrase-2 2.4.2.30 0.878
4hlm 16STankyrase-2 2.4.2.30 0.877
4l10 A63Tankyrase-2 2.4.2.30 0.859
4hkn LU2Tankyrase-2 2.4.2.30 0.857
4kzu A73Tankyrase-2 2.4.2.30 0.856
4l0s 1UZTankyrase-2 2.4.2.30 0.856
4l34 1VGTankyrase-2 2.4.2.30 0.856
4l09 1URTankyrase-2 2.4.2.30 0.855
4l0t 1V0Tankyrase-2 2.4.2.30 0.854
4kzl 20DTankyrase-2 2.4.2.30 0.853
4hmh F94Tankyrase-2 2.4.2.30 0.845
4bs4 A64Tankyrase-2 2.4.2.30 0.844
4hki FLNTankyrase-2 2.4.2.30 0.841
4l0v 1V1Tankyrase-2 2.4.2.30 0.838
4bus 32FTankyrase-2 2.4.2.30 0.836
4bu9 08CTankyrase-2 2.4.2.30 0.835
4buf F36Tankyrase-2 2.4.2.30 0.824
4bux F35Tankyrase-2 2.4.2.30 0.822
4l33 F70Tankyrase-2 2.4.2.30 0.822
4buv 16ITankyrase-2 2.4.2.30 0.821
4hkk AGITankyrase-2 2.4.2.30 0.820
4l0i 1UWTankyrase-2 2.4.2.30 0.820
4bud 29FTankyrase-2 2.4.2.30 0.819
4hlh 20DTankyrase-2 2.4.2.30 0.819
4l2k 1V8Tankyrase-2 2.4.2.30 0.818
4but 31FTankyrase-2 2.4.2.30 0.815
4l2g 1V4Tankyrase-2 2.4.2.30 0.791
4l31 F08Tankyrase-2 2.4.2.30 0.788
4l32 1VFTankyrase-2 2.4.2.30 0.785
4buu F38Tankyrase-2 2.4.2.30 0.783
4bui W2ETankyrase-2 2.4.2.30 0.779
3kr8 XAVTankyrase-2 2.4.2.30 0.778
4bue JQFTankyrase-2 2.4.2.30 0.773
4avw G18Tankyrase-2 2.4.2.30 0.772
4buw F33Tankyrase-2 2.4.2.30 0.771
4l2f 1V3Tankyrase-2 2.4.2.30 0.766
4avu LDRTankyrase-2 2.4.2.30 0.764
4hl5 15WTankyrase-2 2.4.2.30 0.762
3u9y 09LTankyrase-2 2.4.2.30 0.706
4bjb P34Tankyrase-2 2.4.2.30 0.705
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.689
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.685
4bj9 UHBTankyrase-2 2.4.2.30 0.684
4bjc RPBTankyrase-2 2.4.2.30 0.684
4mt9 2D6Tankyrase-1 2.4.2.30 0.684
4pnr G18Tankyrase-2 2.4.2.30 0.681
4pnm NU1Tankyrase-2 2.4.2.30 0.676
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.674
4msg 2C6Tankyrase-1 2.4.2.30 0.665
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.664
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.663
4hhz 15SPoly [ADP-ribose] polymerase 1 2.4.2.30 0.663
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5f 0N7Polymerase acidic protein / 0.656
4f1l 0RYPoly [ADP-ribose] polymerase 14 2.4.2.30 0.655
4tkg 09LTankyrase-2 2.4.2.30 0.655
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.654
2rcw AAIPoly [ADP-ribose] polymerase 1 2.4.2.30 0.651