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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hkk AGI Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hkk AGITankyrase-2 2.4.2.30 0.865
4l34 1VGTankyrase-2 2.4.2.30 0.837
4hlm 16STankyrase-2 2.4.2.30 0.836
4l09 1URTankyrase-2 2.4.2.30 0.835
4l0v 1V1Tankyrase-2 2.4.2.30 0.834
4l10 A63Tankyrase-2 2.4.2.30 0.834
4l0t 1V0Tankyrase-2 2.4.2.30 0.833
4kzl 20DTankyrase-2 2.4.2.30 0.832
4kzu A73Tankyrase-2 2.4.2.30 0.831
4bs4 A64Tankyrase-2 2.4.2.30 0.825
4bux F35Tankyrase-2 2.4.2.30 0.821
4hlf 15ZTankyrase-2 2.4.2.30 0.820
4l0s 1UZTankyrase-2 2.4.2.30 0.820
4hki FLNTankyrase-2 2.4.2.30 0.818
4bus 32FTankyrase-2 2.4.2.30 0.816
4bu9 08CTankyrase-2 2.4.2.30 0.815
4hlg 20BTankyrase-2 2.4.2.30 0.803
4hkn LU2Tankyrase-2 2.4.2.30 0.802
4l33 F70Tankyrase-2 2.4.2.30 0.799
4buf F36Tankyrase-2 2.4.2.30 0.797
4l2k 1V8Tankyrase-2 2.4.2.30 0.797
4bud 29FTankyrase-2 2.4.2.30 0.796
4but 31FTankyrase-2 2.4.2.30 0.796
4hlh 20DTankyrase-2 2.4.2.30 0.794
4buv 16ITankyrase-2 2.4.2.30 0.792
4l0i 1UWTankyrase-2 2.4.2.30 0.790
4buu F38Tankyrase-2 2.4.2.30 0.784
4l31 F08Tankyrase-2 2.4.2.30 0.782
4hl5 15WTankyrase-2 2.4.2.30 0.772
4bue JQFTankyrase-2 2.4.2.30 0.771
4buw F33Tankyrase-2 2.4.2.30 0.771
4l32 1VFTankyrase-2 2.4.2.30 0.770
4l2f 1V3Tankyrase-2 2.4.2.30 0.766
4l2g 1V4Tankyrase-2 2.4.2.30 0.766
4bui W2ETankyrase-2 2.4.2.30 0.763
4avw G18Tankyrase-2 2.4.2.30 0.751
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
5aku 29FTankyrase-2 2.4.2.30 0.744
4avu LDRTankyrase-2 2.4.2.30 0.738
4hmh F94Tankyrase-2 2.4.2.30 0.736
4hlk 431Tankyrase-2 2.4.2.30 0.729
3kr8 XAVTankyrase-2 2.4.2.30 0.709
4pnr G18Tankyrase-2 2.4.2.30 0.685
3u9y 09LTankyrase-2 2.4.2.30 0.683
4bjb P34Tankyrase-2 2.4.2.30 0.677
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.671
4li6 1XOTankyrase-1 2.4.2.30 0.671
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.670
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4bj9 UHBTankyrase-2 2.4.2.30 0.657
1e90 MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.652
4krs 1SXTankyrase-1 2.4.2.30 0.652
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.651