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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gih 0X5 Non-receptor tyrosine-protein kinase TYK2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gih 0X5Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.952
4gj2 0XHNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.893
4gii 0X6Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.870
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4gj3 0XPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.721
4gmy 0X5Tyrosine-protein kinase JAK2 / 0.690
4e5f 0N7Polymerase acidic protein / 0.660
4gfo 0X2Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.660
4bdi HAUSerine/threonine-protein kinase Chk2 2.7.11.1 0.659
4jaj XU1Aurora kinase A 2.7.11.1 0.659
2np8 CC3Aurora kinase A 2.7.11.1 0.658