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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fl2 ANP Tyrosine-protein kinase SYK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 1.080
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.974
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.770
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.749
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.747
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.707
3ort AGSSerine/threonine protein kinase / 0.700
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.699
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.699
2ozo ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.697
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.693
3ork AGSSerine/threonine protein kinase / 0.690
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.688
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.682
3llt ANPProtein serine/threonine kinase-1 / 0.679
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.679
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.677
3ryh GTPTubulin alpha chain / 0.677
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.677
4lrj ANPUncharacterized protein / 0.677
4bix ADPSensor histidine kinase CpxA / 0.676
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4k2r ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.673
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.672
2pyw ADPMethylthioribose kinase 2.7.1.100 0.672
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.672
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.671
4ee3 UDHBeta-1,4-galactosyltransferase 1 / 0.671
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.667
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.666
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.666
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.665
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.664
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.662
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.662
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.662
2pup ADPMethylthioribose kinase 2.7.1.100 0.661
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.661
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.660
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.658
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.658
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.658
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.657
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.656
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.655
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.655
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.655
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.654
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.652
4prx ADPDNA gyrase subunit B / 0.652
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.651
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4utd ACPAurora kinase A 2.7.11.1 0.651
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.650
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.650
2ior ADPChaperone protein HtpG / 0.650
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650