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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eso NAP Putative oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eso NAPPutative oxidoreductase / 1.298
3d3w NAPL-xylulose reductase 1.1.1.10 0.784
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.775
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.773
3l77 NJPShort-chain alcohol dehydrogenase / 0.770
1xkq NDPUncharacterized protein / 0.766
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.766
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.764
1ipe NDPTropinone reductase 2 1.1.1.236 0.763
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.749
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.748
3tn7 NJPShort-chain alcohol dehydrogenase / 0.747
1pr9 NAPL-xylulose reductase 1.1.1.10 0.744
4j7x NAPSepiapterin reductase 1.1.1.153 0.736
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.735
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.735
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.734
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.731
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.730
4j7u NAPSepiapterin reductase 1.1.1.153 0.730
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.729
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.728
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.726
4b79 NADProbable short-chain dehydrogenase / 0.725
3s55 NADPutative short-chain dehydrogenase/reductase / 0.724
3r3s NADPutative oxidoreductase / 0.722
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.721
3o26 NDPSalutaridine reductase / 0.719
4kwh NAPReductase homolog / 0.719
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.717
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.715
1zem NADXylitol dehydrogenase / 0.714
2yut NAPPutative short-chain oxidoreductase / 0.714
3p19 NDPPutative blue fluorescent protein / 0.714
2bd0 NAPSepiapterin reductase / 0.713
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.713
4bmv NAPShort-chain dehydrogenase / 0.713
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.713
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.712
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.709
3qrw NDPPutative ketoacyl reductase 1.3.1 0.707
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.707
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.704
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.703
3u4c NDPNADPH-dependent reductase BacG / 0.702
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.700
5d2e NAPMlnE / 0.700
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.699
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.697
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.697
2wsb NADGalactitol dehydrogenase / 0.695
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.695
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.695
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.695
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.694
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.693
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.692
2wdz NADGalactitol dehydrogenase / 0.691
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.691
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.691
2jah NDPClavaldehyde dehydrogenase / 0.690
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.688
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.688
5jyd NADShort chain dehydrogenase / 0.688
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.687
4qed NAPElxO / 0.686
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.685
4qec NAPElxO / 0.685
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.683
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.682
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.681
4nbw NADShort-chain dehydrogenase/reductase SDR / 0.680
1oaa NAPSepiapterin reductase 1.1.1.153 0.679
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.679
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.679
4yag NAIC alpha-dehydrogenase / 0.679
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.678
4fn4 NADShort chain dehydrogenase / 0.677
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.677
1ae1 NAPTropinone reductase 1 / 0.676
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.676
2v6g NAP3-oxo-Delta(4,5)-steroid 5-beta-reductase / 0.676
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.676
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.675
4dbz NDPPutative ketoacyl reductase 1.3.1 0.675
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.674
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.674
3mje NDPAmphB / 0.673
2c29 NAPDihydroflavonol 4-reductase / 0.672
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.672
4l4x NDPAmphI / 0.672
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.671
3sju NDPKeto reductase / 0.671
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.670
4hwk NAPSepiapterin reductase 1.1.1.153 0.670
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.669
4n5n NAPAcetoacetyl-CoA reductase 1.1.1.36 0.666
1x7g NAPPutative ketoacyl reductase 1.3.1 0.665
3f1k NAPUncharacterized oxidoreductase YciK 1 0.665
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.665
4hxy NDPPlm1 / 0.665
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.665
2vwp NDPGlucose 1-dehydrogenase / 0.664
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.663
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.663
3tox NAPPutative oxidoreductase / 0.663
5lc1 NADL-threonine 3-dehydrogenase / 0.663
1x7h NDPPutative ketoacyl reductase 1.3.1 0.661
4e5y NDPGDP-L-fucose synthase 1.1.1.271 0.661
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.660
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.660
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.659
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.659
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.659
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.658
3wmx NADNAD dependent epimerase/dehydratase / 0.658
1qyv NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.655
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.655
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.654
3tsc NADUncharacterized protein / 0.654
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.653
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.653
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
3ak4 NADNADH-dependent quinuclidinone reductase / 0.651
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.651
2yy7 NADL-threonine dehydrogenase / 0.650
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.650