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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ein NOH Thymidylate synthase 2.1.1.45

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ein NOHThymidylate synthase 2.1.1.45 1.142
4e5o UMPThymidylate synthase 2.1.1.45 1.065
5by6 UMPThymidylate synthase / 1.037
4eb4 UMPThymidylate synthase 2.1.1.45 1.025
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.992
4dq1 UMPThymidylate synthase / 0.972
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.968
4irr UMPThymidylate synthase / 0.956
4isk UMPThymidylate synthase / 0.953
1f28 UMPThymidylate synthase 2.1.1.45 0.932
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.923
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.922
4h0u UMPThymidylate synthase / 0.900
2fto TMPThymidylate synthase / 0.897
4fox UMPThymidylate synthase ThyA / 0.894
3qj7 UMPThymidylate synthase ThyA / 0.888
1tys TMPThymidylate synthase / 0.887
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.865
4iqq UMPThymidylate synthase / 0.816
1bid UMPThymidylate synthase / 0.811
2vet UMPThymidylate synthase / 0.800
4psg NOHThymidylate synthase / 0.796
1nja DCMThymidylate synthase / 0.778
2tsr UMPThymidylate synthase 2.1.1.45 0.778
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.773
1bp0 UMPThymidylate synthase / 0.766
1tsy UMPThymidylate synthase / 0.758
2g86 UMPThymidylate synthase / 0.749
1vza UMPThymidylate synthase / 0.746
3bgx TMPThymidylate synthase / 0.745
1jmf UMPThymidylate synthase / 0.741
2g8a UMPThymidylate synthase / 0.738
1tsx UMPThymidylate synthase / 0.734
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.725
2tdm UMPThymidylate synthase / 0.723
1bp6 UMPThymidylate synthase / 0.715
3lzx NAPFerredoxin--NADP reductase 2 1.18.1.2 0.714
1njd UMPThymidylate synthase / 0.706
1tsv UMPThymidylate synthase / 0.706
2g8d UMPThymidylate synthase / 0.705
1vzb UMPThymidylate synthase / 0.704
3hb8 UMPThymidylate synthase 2.1.1.45 0.700
1jmg UMPThymidylate synthase / 0.699
1bpj UMPThymidylate synthase / 0.695
4y0k NAPAntE / 0.688
3lzw NAPFerredoxin--NADP reductase 2 1.18.1.2 0.686
1tdc UMPThymidylate synthase / 0.674
1njb UMPThymidylate synthase / 0.670
1jmh UMPThymidylate synthase / 0.666
1ci7 UMPThymidylate synthase 2.1.1.45 0.662
4xsd UMPThymidylate synthase 2.1.1.45 0.661
4zrn UPGUDP-glucose 4-epimerase, putative / 0.659
1jmi UMPThymidylate synthase / 0.653
1tdu DURThymidylate synthase / 0.653
3c1o NAPEugenol synthase / 0.653
3ubm COAFormyl-CoA:oxalate CoA-transferase / 0.652
2zzc NAPThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.650
4gcm NAPThioredoxin reductase 1.8.1.9 0.650