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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4egk RDC Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4egk RDCHeat shock protein HSP 90-alpha / 1.046
1qy8 RDIEndoplasmin / 0.878
1u0z RDCEndoplasmin / 0.846
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.834
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.831
4bqj XKLHeat shock protein HSP 90-alpha / 0.804
2xd6 XD6ATP-dependent molecular chaperone HSP82 / 0.803
3inx JZCHeat shock protein HSP 90-alpha / 0.801
3hek BD0Heat shock protein HSP 90-alpha / 0.800
2xx2 13CATP-dependent molecular chaperone HSP82 / 0.798
2yk2 YJWHeat shock protein HSP 90-alpha / 0.793
2xjx XJXHeat shock protein HSP 90-alpha / 0.791
2xx4 13IATP-dependent molecular chaperone HSP82 / 0.790
2xjj L81Heat shock protein HSP 90-alpha / 0.788
3eko PYUHeat shock protein HSP 90-alpha / 0.788
3k98 1RCHeat shock protein HSP 90-alpha / 0.786
2q8i RDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 2.7.11.2 0.782
2xab VHDHeat shock protein HSP 90-alpha / 0.774
2ye9 2D4Heat shock protein HSP 90-alpha / 0.772
3k99 PFTHeat shock protein HSP 90-alpha / 0.769
2bt0 CT5Heat shock protein HSP 90-alpha / 0.765
3ekr PY9Heat shock protein HSP 90-alpha / 0.757
4ce1 7FKATP-dependent molecular chaperone HSP82 / 0.755
2wer RDCATP-dependent molecular chaperone HSP82 / 0.754
3k97 4CDHeat shock protein HSP 90-alpha / 0.754
2yjw YJWHeat shock protein HSP 90-alpha / 0.751
2iws NP4ATP-dependent molecular chaperone HSP82 / 0.745
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.744
4egh 0OYHeat shock protein HSP 90-alpha / 0.743
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.739
2ye4 2FYHeat shock protein HSP 90-alpha / 0.738
2cgf P2NATP-dependent molecular chaperone HSP82 / 0.737
2ccu 2D9Heat shock protein HSP 90-alpha / 0.732
2byi 2DDHeat shock protein HSP 90-alpha / 0.728
2yi5 YI5Heat shock protein HSP 90-alpha / 0.726
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.725
1yc1 4BCHeat shock protein HSP 90-alpha / 0.720
2bsm BSMHeat shock protein HSP 90-alpha / 0.718
2bz5 AB4Heat shock protein HSP 90-alpha / 0.717
4mp7 PFT[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.703
2bre KJ2ATP-dependent molecular chaperone HSP82 / 0.700
4ce2 BO5ATP-dependent molecular chaperone HSP82 / 0.695
2xht C0YHeat shock protein HSP 90-alpha / 0.689
2gfd RDAEndoplasmin / 0.687
2fxs RDAATP-dependent molecular chaperone HSP82 / 0.671
4ce3 L4VATP-dependent molecular chaperone HSP82 / 0.662
2yi7 BZ8Heat shock protein HSP 90-alpha / 0.653
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.653
2r9k SGIBeta-galactoside-specific lectin 1 / 0.651
2xx5 13NATP-dependent molecular chaperone HSP82 / 0.650
3hhu 819Heat shock protein HSP 90-alpha / 0.650