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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e6d 0NU Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e6d 0NUTyrosine-protein kinase JAK2 / 0.825
4i5c C5ITyrosine-protein kinase JAK1 / 0.811
4e5i 0N9Polymerase acidic protein / 0.744
4e4n 0NLTyrosine-protein kinase JAK1 / 0.735
4ei4 0Q2Tyrosine-protein kinase JAK1 / 0.727
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.713
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.706
2qhm 7CSSerine/threonine-protein kinase Chk1 2.7.11.1 0.703
4f08 1RSTyrosine-protein kinase JAK2 / 0.697
4f09 JAKTyrosine-protein kinase JAK2 / 0.694
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.693
3bht MFRCyclin-dependent kinase 2 2.7.11.22 0.681
2pzr ACPFibroblast growth factor receptor 2 / 0.675
3rwp ABQ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.663
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.663
3eyh IZATyrosine-protein kinase JAK1 / 0.660
3lxk MI1Tyrosine-protein kinase JAK3 2.7.10.2 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
4ivd 15TTyrosine-protein kinase JAK1 / 0.659
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.657
4k77 1Q4Tyrosine-protein kinase JAK1 / 0.651
2x6d X6DAurora kinase A 2.7.11.1 0.650