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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e4n 0NL Tyrosine-protein kinase JAK1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e4n 0NLTyrosine-protein kinase JAK1 / 0.889
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4i5c C5ITyrosine-protein kinase JAK1 / 0.738
4e6d 0NUTyrosine-protein kinase JAK2 / 0.735
4ei4 0Q2Tyrosine-protein kinase JAK1 / 0.719
4f08 1RSTyrosine-protein kinase JAK2 / 0.714
4fk6 0UJTyrosine-protein kinase JAK1 / 0.699
4gu9 4GUFocal adhesion kinase 1 2.7.10.2 0.688
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.678
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.671
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.670
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.666
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.658
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.657
4e4l 0NHTyrosine-protein kinase JAK1 / 0.656
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.655
3qtw X3ACyclin-dependent kinase 2 2.7.11.22 0.653
3cr0 809Wee1-like protein kinase 2.7.10.2 0.650