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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dus 0MP Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dus 0MPBeta-secretase 1 3.4.23.46 1.225
4dh6 0KNBeta-secretase 1 3.4.23.46 1.034
4exg 916Beta-secretase 1 3.4.23.46 1.019
3qi1 C6ABeta-secretase 1 3.4.23.46 1.005
4ke0 1R8Beta-secretase 1 3.4.23.46 0.994
4ewo 996Beta-secretase 1 3.4.23.46 0.988
4ke1 1R6Beta-secretase 1 3.4.23.46 0.972
2vie VG0Beta-secretase 1 3.4.23.46 0.957
3nsh 957Beta-secretase 1 3.4.23.46 0.950
4i0i 957Beta-secretase 1 3.4.23.46 0.950
4k8s 1QTBeta-secretase 1 3.4.23.46 0.932
4i0h 1BLBeta-secretase 1 3.4.23.46 0.918
2vj7 VG6Beta-secretase 1 3.4.23.46 0.902
3k5c 0BIBeta-secretase 1 3.4.23.46 0.899
2xfj VG5Beta-secretase 1 3.4.23.46 0.898
3k5g BJCBeta-secretase 1 3.4.23.46 0.894
2vj6 VG5Beta-secretase 1 3.4.23.46 0.888
2vnm CM8Beta-secretase 1 3.4.23.46 0.881
2viy VG3Beta-secretase 1 3.4.23.46 0.879
3veu 0GOBeta-secretase 1 3.4.23.46 0.854
2xfi XFIBeta-secretase 1 3.4.23.46 0.852
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.844
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.834
2vnn CM7Beta-secretase 1 3.4.23.46 0.830
4lxm 1YUBeta-secretase 1 3.4.23.46 0.824
4i0j 842Beta-secretase 1 3.4.23.46 0.820
2p8h MY9Beta-secretase 1 3.4.23.46 0.819
3cib 314Beta-secretase 1 3.4.23.46 0.817
2b8v 3BNBeta-secretase 1 3.4.23.46 0.808
2xfk AA9Beta-secretase 1 3.4.23.46 0.807
4lxk 1YTBeta-secretase 1 3.4.23.46 0.804
2viz VG4Beta-secretase 1 3.4.23.46 0.803
4dpf 0LGBeta-secretase 1 3.4.23.46 0.803
2hiz LIJBeta-secretase 1 3.4.23.46 0.801
2vj9 VG7Beta-secretase 1 3.4.23.46 0.794
3n4l 842Beta-secretase 1 3.4.23.46 0.793
3cic 316Beta-secretase 1 3.4.23.46 0.786
4lxa 1YSBeta-secretase 1 3.4.23.46 0.784
4dpi 0N1Beta-secretase 1 3.4.23.46 0.782
4d89 BXDBeta-secretase 1 3.4.23.46 0.779
3dv5 BAVBeta-secretase 1 3.4.23.46 0.778
3vf3 0GSBeta-secretase 1 3.4.23.46 0.774
3pww ROCEndothiapepsin 3.4.23.22 0.758
3i25 MV7Beta-secretase 1 3.4.23.46 0.746
2vij C44Beta-secretase 1 3.4.23.46 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3lpi Z74Beta-secretase 1 3.4.23.46 0.740
3vg1 0GTBeta-secretase 1 3.4.23.46 0.734
2wez ZYEBeta-secretase 1 3.4.23.46 0.729
3ohf 3HFBeta-secretase 1 3.4.23.46 0.728
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.727
3tpr 5HABeta-secretase 1 3.4.23.46 0.724
4fco 0U4Beta-secretase 1 3.4.23.46 0.724
2vkm BSDBeta-secretase 1 3.4.23.46 0.723
1w51 L01Beta-secretase 1 3.4.23.46 0.721
1e80 0GQEndothiapepsin 3.4.23.22 0.720
3pi5 3P5Beta-secretase 1 3.4.23.46 0.712
2oah QINBeta-secretase 1 3.4.23.46 0.696
3dm6 757Beta-secretase 1 3.4.23.46 0.684
3own 3OXRenin 3.4.23.15 0.683
2jji 0QSEndothiapepsin 3.4.23.22 0.680
2f3f AXFBeta-secretase 1 3.4.23.46 0.670
4e5f 0N7Polymerase acidic protein / 0.660
2g94 ZPQBeta-secretase 1 3.4.23.46 0.656
1gvw 0EMEndothiapepsin 3.4.23.22 0.655
2jjj 0QSEndothiapepsin 3.4.23.22 0.652
1b6m PI6Gag-Pol polyprotein 3.4.23.16 0.650