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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c59 FEF Cyclin-G-associated kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c59 FEFCyclin-G-associated kinase 2.7.11.1 0.990
3eb0 DRKUncharacterized protein / 0.720
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.695
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.692
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.690
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.684
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.681
4c57 FEFCyclin-G-associated kinase 2.7.11.1 0.676
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.674
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
1unh IXMCyclin-dependent-like kinase 5 2.7.11.1 0.663
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
2bhe BRYCyclin-dependent kinase 2 2.7.11.22 0.661
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1nmd ATPMajor actin / 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2d09 FLVBiflaviolin synthase CYP158A2 / 0.660
2jey HLOAcetylcholinesterase 3.1.1.7 0.660
2oap ANPType II secretion system protein (GspE-2) / 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
2zs9 ADPPantothenate kinase 2.7.1.33 0.660
3cwq ADPParA family chromosome partitioning protein / 0.660
3f8p NADNADH oxidase/thioredoxin reductase / 0.660
3f8r NAPNADH oxidase/thioredoxin reductase / 0.660
3fzf ATPHeat shock cognate 71 kDa protein / 0.660
3u9d ATPActin, alpha skeletal muscle / 0.660
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.660
3zzn ADPL-lactate dehydrogenase / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650