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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b4o NDP Epimerase family protein SDR39U1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b4o NDPEpimerase family protein SDR39U1 / 1.202
2c29 NAPDihydroflavonol 4-reductase / 0.847
4hxy NDPPlm1 / 0.759
3c3x NAPEugenol synthase 1 1.1.1.318 0.757
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.744
1i3l NADUDP-glucose 4-epimerase / 0.736
4u7w NDPMxaA / 0.732
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.727
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.725
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.723
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.721
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.717
3mje NDPAmphB / 0.717
3icp NADNAD-dependent epimerase/dehydratase / 0.716
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.714
4xyb NDPFormate dehydrogenase / 0.711
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.710
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.710
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.710
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.709
5d2e NAPMlnE / 0.709
3a4v NADNDP-sugar epimerase / 0.707
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.706
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.704
4qec NAPElxO / 0.704
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.703
1orr NADCDP-paratose 2-epimerase / 0.702
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.700
4hwk NAPSepiapterin reductase 1.1.1.153 0.699
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.698
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.698
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.698
1x7g NAPPutative ketoacyl reductase 1.3.1 0.695
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.695
2yjz NAPMetalloreductase STEAP4 1.16.1 0.694
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.694
1rpn NDPGDP-mannose 4,6-dehydratase / 0.693
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.692
2yy7 NADL-threonine dehydrogenase / 0.691
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.690
1oaa NAPSepiapterin reductase 1.1.1.153 0.690
3s55 NADPutative short-chain dehydrogenase/reductase / 0.690
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.689
2r6j NDPEugenol synthase 1 1.1.1.318 0.689
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.689
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.688
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.688
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.688
3ai3 NDPNADPH-sorbose reductase / 0.687
4qed NAPElxO / 0.687
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.685
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.684
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.684
2qw8 NAPEugenol synthase 1 1.1.1.318 0.684
4imp NDPPolyketide synthase extender modules 3-4 / 0.684
1x7h NDPPutative ketoacyl reductase 1.3.1 0.683
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.682
3sju NDPKeto reductase / 0.682
2jah NDPClavaldehyde dehydrogenase / 0.680
3ko8 NADNAD-dependent epimerase/dehydratase / 0.680
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.679
3ajr NADNDP-sugar epimerase / 0.679
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.678
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.678
4l4x NDPAmphI / 0.678
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.677
4twr NADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase / 0.676
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.675
3sx2 NADUncharacterized protein / 0.675
3uce NDPDehydrogenase / 0.675
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.675
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.675
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.674
4e5y NDPGDP-L-fucose synthase 1.1.1.271 0.674
5a1t NAIL-lactate dehydrogenase / 0.674
2yut NAPPutative short-chain oxidoreductase / 0.673
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.672
1t2a NDPGDP-mannose 4,6 dehydratase 4.2.1.47 0.671
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.671
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.671
5jla NADPutative short-chain dehydrogenase/reductase / 0.670
3l77 NJPShort-chain alcohol dehydrogenase / 0.669
3u4c NDPNADPH-dependent reductase BacG / 0.669
3wmx NADNAD dependent epimerase/dehydratase / 0.668
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.667
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.666
3qrw NDPPutative ketoacyl reductase 1.3.1 0.666
4egb NADdTDP-glucose 4,6-dehydratase / 0.666
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.666
4j7x NAPSepiapterin reductase 1.1.1.153 0.665
2wsb NADGalactitol dehydrogenase / 0.663
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.662
4dbz NDPPutative ketoacyl reductase 1.3.1 0.662
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.662
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.662
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.660
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.659
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.659
4ros APRMalate dehydrogenase / 0.659
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.657
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.657
4fn4 NADShort chain dehydrogenase / 0.656
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.655
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.653
3oab DSTGeranyl diphosphate synthase large subunit / 0.653
2z1m NDPGDP-mannose 4,6-dehydratase / 0.652
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.651
1pr9 NAPL-xylulose reductase 1.1.1.10 0.651
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.650
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.650
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.650