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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b0g VEK Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b0g VEKAurora kinase A 2.7.11.1 0.925
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2x6d X6DAurora kinase A 2.7.11.1 0.705
1oec AA2Fibroblast growth factor receptor 2 / 0.699
2vgp AD6Aurora kinase B-A 2.7.11.1 0.687
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.682
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.681
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.670
3ztx ZTXAurora kinase B-A 2.7.11.1 0.660
4ekl 0RFRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.660
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.659
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.654
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.654
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
3cqw CQWRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.653
3uo5 0BXAurora kinase A 2.7.11.1 0.652
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.651
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650