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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zls 92P Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.834
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e6d 0NUTyrosine-protein kinase JAK2 / 0.713
4f08 1RSTyrosine-protein kinase JAK2 / 0.712
3bht MFRCyclin-dependent kinase 2 2.7.11.22 0.711
2qhm 7CSSerine/threonine-protein kinase Chk1 2.7.11.1 0.691
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.689
2yfx VGHALK tyrosine kinase receptor 2.7.10.1 0.685
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.685
5aac VGHALK tyrosine kinase receptor 2.7.10.1 0.685
4i5c C5ITyrosine-protein kinase JAK1 / 0.682
4ans VGHALK tyrosine kinase receptor 2.7.10.1 0.679
5aab VGHALK tyrosine kinase receptor 2.7.10.1 0.674
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.674
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.671
4anq VGHALK tyrosine kinase receptor 2.7.10.1 0.671
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.668
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.665
4ccu AWFALK tyrosine kinase receptor 2.7.10.1 0.665
4aoi 4K0Hepatocyte growth factor receptor 2.7.10.1 0.664
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4ccb OFGALK tyrosine kinase receptor 2.7.10.1 0.664
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
4f09 JAKTyrosine-protein kinase JAK2 / 0.655
5aaa VGHALK tyrosine kinase receptor 2.7.10.1 0.654
2in6 839Wee1-like protein kinase 2.7.10.2 0.653
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.652
3c4e C4ESerine/threonine-protein kinase pim-1 2.7.11.1 0.651
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.650