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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3x2e NAI Adenosylhomocysteinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3x2e NAIAdenosylhomocysteinase / 0.956
3x2f NAIAdenosylhomocysteinase / 0.705
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.702
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.702
3d64 NADAdenosylhomocysteinase / 0.702
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.695
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.689
1o6z NADMalate dehydrogenase / 0.688
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.687
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.687
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.682
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.682
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.679
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.679
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.677
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.677
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.675
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.675
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.673
4c4o NADSADH / 0.673
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.672
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.671
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.669
1guy NADMalate dehydrogenase / 0.668
2dfv NADL-threonine 3-dehydrogenase / 0.667
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.666
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.666
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.665
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.665
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.664
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.661
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.661
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.659
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.658
1uxj NADMalate dehydrogenase / 0.657
3ggo NAIPrephenate dehydrogenase / 0.657
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.657
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.656
1uxk NADMalate dehydrogenase / 0.653
4jji NADAlcohol dehydrogenase class-3 / 0.653
2vhx NADAlanine dehydrogenase 1.4.1.1 0.652
4cpd NADAlcohol dehydrogenase / 0.652
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.650
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.650