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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tjl FMN NADPH dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3tjl FMNNADPH dehydrogenase / 1.281
4m5p FMNNADPH dehydrogenase / 1.272
4df2 FMNNADPH dehydrogenase / 1.232
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 1.124
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 1.123
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 1.122
4tmc FMNOld yellow enzyme / 1.110
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 1.105
1gwj FMNMorphinone reductase / 1.068
3p8j FMNPentaerythritol tetranitrate reductase / 1.063
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 1.056
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 1.052
4awt FMNNADH:flavin oxidoreductase Sye1 / 1.045
4aws FMNNADH:flavin oxidoreductase Sye1 / 1.035
3p84 FMNPentaerythritol tetranitrate reductase / 1.033
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 1.024
4qai FMNNADPH dehydrogenase / 1.021
1oya FMNNADPH dehydrogenase 1 1.6.99.1 1.020
4utm FNRXenobiotic reductase / 1.018
3f03 FMNPentaerythritol tetranitrate reductase / 1.015
4utk FNRXenobiotic reductase / 1.010
2gqa FMNNADH:flavin oxidoreductase Sye1 / 1.002
3l67 FMNXenobiotic reductase / 1.001
3n14 FMNXenobiotic reductase / 1.001
2h8x FMNXenA / 1.000
4uth FMNXenobiotic reductase / 0.993
1h50 FMNPentaerythritol tetranitrate reductase / 0.992
4jic FMNGTN Reductase / 0.991
3l5l FMNXenobiotic reductase / 0.988
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.977
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.965
4tmb FMNOld yellow enzyme / 0.965
3gka FMNN-ethylmaleimide reductase / 0.958
4utl FNRXenobiotic reductase / 0.953
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.951
3hf3 FMNChromate reductase / 0.948
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.947
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.944
4e2d FMNDehydrogenase / 0.931
3p74 FMNPentaerythritol tetranitrate reductase / 0.930
4e2b FMNDehydrogenase / 0.923
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.921
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.921
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.920
3atz FMNProstaglandin F2a synthase / 0.920
1z41 FMNNADPH dehydrogenase / 0.916
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.910
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.905
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.904
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.903
3p62 FMNPentaerythritol tetranitrate reductase / 0.900
3aty FMNProstaglandin F2a synthase / 0.897
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.896
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.894
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.893
1z48 FMNNADPH dehydrogenase / 0.873
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.869
4yco FMNtRNA-dihydrouridine(16) synthase / 0.864
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.861
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.860
3gr8 FMNNADPH dehydrogenase / 0.860
1h63 FMNPentaerythritol tetranitrate reductase / 0.851
2abb FMNPentaerythritol tetranitrate reductase / 0.847
3n19 FNRXenobiotic reductase / 0.847
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.846
3p8i FMNPentaerythritol tetranitrate reductase / 0.842
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.839
1h51 FMNPentaerythritol tetranitrate reductase / 0.833
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.809
3p67 FMNPentaerythritol tetranitrate reductase / 0.800
1z44 FMNNADPH dehydrogenase / 0.799
1vyr FMNPentaerythritol tetranitrate reductase / 0.794
4yl2 FMNLactate oxidase / 0.792
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.786
5ebu FMNLactate oxidase / 0.781
3oix FMNDihydroorotate dehydrogenase / 0.778
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.776
2z6i FMN2-nitropropane dioxygenase / 0.765
2j6x FMNLactate oxidase / 0.760
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.750
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.749
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.748
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.747
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.744
3p82 FMNPentaerythritol tetranitrate reductase / 0.742
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.737
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.727
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.727
2nli FMNLactate oxidase / 0.726
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.719
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.716
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.714
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.714
2e77 FMNLactate oxidase / 0.706
4cw5 FMNDfnA / 0.705
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.705
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.703
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.702
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.700
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.688
4hnb FMNLOV protein / 0.685
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.680
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.679
4nm9 FADBifunctional protein PutA / 0.678
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.675
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.675
3qe2 FMNNADPH--cytochrome P450 reductase / 0.672
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.671
1tj0 FADBifunctional protein PutA 1.5.5.2 0.670
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.670
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.667
2ohh FMNType A flavoprotein FprA 1 0.666
4hmx FMNPyridoxamine 5'-phosphate oxidase / 0.665
2b3d FADModulator of drug activity B / 0.664
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.664
3lcm FADPutative oxidoreductase / 0.664
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.664
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.663
2du2 FMNLactate oxidase / 0.663
2zfa FMNLactate oxidase / 0.663
4bmo FMNProtein NrdI / 0.662
2c12 FADNitroalkane oxidase 1.7.3.1 0.660
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.660
4x2d ATPFic family protein putative filamentation induced by cAMP protein / 0.660
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.660
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.657
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.657
1wuq 8GTGTP cyclohydrolase 1 / 0.657
2bf4 FMNNADPH--cytochrome P450 reductase / 0.657
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.657
4j8p FMNFlavodoxin / 0.657
4z38 FMNMlnA / 0.657
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.656
2z6c FMNPhototropin-1 2.7.11.1 0.655
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.655
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.654
4nmc FADBifunctional protein PutA / 0.654
2z9d FMNFMN-dependent NADH-azoreductase / 0.653
4n82 FMNRibonucleotide reductase (NrdI family protein), putative / 0.653
2ohj FMNType A flavoprotein FprA 1 0.652