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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rhh NAP NADP-dependent glyceraldehyde-3-phosphate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.961
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.832
4nmk NAPAldehyde dehydrogenase / 0.761
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.750
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.734
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.719
4i9b NADPutative betaine aldehyde dehyrogenase / 0.719
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.710
3iwj NADAminoaldehyde dehydrogenase / 0.710
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.706
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.705
2esd NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.696
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.686
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.686
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.682
4nmj NAPAldehyde dehydrogenase / 0.682
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.681
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.678
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.671
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.669
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.668
5dib NADBetaine-aldehyde dehydrogenase / 0.662
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.661
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.660
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.658
4h73 NDPAldehyde dehydrogenase / 0.657
3qfs NAPNADPH--cytochrome P450 reductase / 0.652
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.651
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.650