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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qzg X67 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.904
3qqg X06Cyclin-dependent kinase 2 2.7.11.22 0.835
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.796
3qzf X66Cyclin-dependent kinase 2 2.7.11.22 0.791
3qqh X0ACyclin-dependent kinase 2 2.7.11.22 0.756
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.728
3fz1 B98Cyclin-dependent kinase 2 2.7.11.22 0.703
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.681
3q9z TXQCasein kinase II subunit alpha 2.7.11.1 0.679
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.678
2btr U73Cyclin-dependent kinase 2 2.7.11.22 0.675
4mf0 29ZTyrosine-protein kinase ITK/TSK 2.7.10.2 0.674
4eon 1ROCyclin-dependent kinase 2 2.7.11.22 0.671
3ma3 01ISerine/threonine-protein kinase pim-1 2.7.11.1 0.662
4ap7 F47Hepatocyte growth factor receptor 2.7.10.1 0.662
2r3g SC9Cyclin-dependent kinase 2 2.7.11.22 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.657
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.656
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.655
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.653
3f88 3HTGlycogen synthase kinase-3 beta 2.7.11.26 0.653
4egk RDCHeat shock protein HSP 90-alpha / 0.653
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.652
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.651