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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ou7 SAM SAM-dependent methyltransferase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ou7 SAMSAM-dependent methyltransferase / 1.031
3ou6 SAMSAM-dependent methyltransferase / 0.831
4nec SAHPutative SAM-dependent methyltransferase / 0.742
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.714
1qan SAHrRNA adenine N-6-methyltransferase 2.1.1.184 0.698
5f8f SFGPossible transcriptional regulatory protein / 0.693
3cbg SAHO-methyltransferase / 0.692
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.692
4yac NAIC alpha-dehydrogenase / 0.687
3ou2 SAHSAM-dependent methyltransferase / 0.681
1nbh SAMGlycine N-methyltransferase 2.1.1.20 0.680
5je2 SAHMethyl transferase / 0.678
1d2h SAHGlycine N-methyltransferase 2.1.1.20 0.677
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.677
3duw SAHO-methyltransferase, putative / 0.676
3v8v SAMRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.674
1y9d FADPyruvate oxidase 1.2.3.3 0.671
4ube 2FAAdenosine kinase 2.7.1.20 0.670
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.669
5e8j SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.669
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.667
2hms NAIKtr system potassium uptake protein A / 0.667
7mht SAHModification methylase HhaI 2.1.1.37 0.666
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.665
4pgh SAMCaffeic acid O-methyltransferase / 0.665
1wy7 SAHUncharacterized protein / 0.663
2gs9 SAHUncharacterized protein / 0.663
2p35 SAHTrans-aconitate 2-methyltransferase / 0.663
3nmu SAMFibrillarin-like rRNA/tRNA 2'-O-methyltransferase / 0.662
4lv5 ADPRhoptry protein 5B / 0.660
3gu3 SAHMethyltransferase / 0.659
5je4 SAHMethyl transferase / 0.659
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.658
3rw9 DSHSpermidine synthase 2.5.1.16 0.658
2a1u FADElectron transfer flavoprotein subunit alpha, mitochondrial / 0.657
2bh2 SAH23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD / 0.657
2yy7 NADL-threonine dehydrogenase / 0.657
2nyu SAMrRNA methyltransferase 2, mitochondrial / 0.655
3sgl SAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.655
2bzg SAHThiopurine S-methyltransferase 2.1.1.67 0.654
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.654
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.653
2o07 MTASpermidine synthase 2.5.1.16 0.652
2pkk 2FAAdenosine kinase 2.7.1.20 0.652
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.651
3evb SAHGenome polyprotein 2.1.1.56 0.651
1ahh NAD7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.650
1f3l SAHProtein arginine N-methyltransferase 3 / 0.650
2ytz SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.650