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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3oe4 610 Catechol O-methyltransferase 2.1.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3oe4 610Catechol O-methyltransferase 2.1.1.6 1.093
3hvi 619Catechol O-methyltransferase 2.1.1.6 0.975
3ozt OZZCatechol O-methyltransferase 2.1.1.6 0.964
3oe5 611Catechol O-methyltransferase 2.1.1.6 0.947
3r6t LU1Catechol O-methyltransferase 2.1.1.6 0.933
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.925
3nwb 659Catechol O-methyltransferase 2.1.1.6 0.888
3ozs OZSCatechol O-methyltransferase 2.1.1.6 0.881
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.872
3nwe 662Catechol O-methyltransferase 2.1.1.6 0.872
3a7d FBNCatechol O-methyltransferase 2.1.1.6 0.869
3nw9 637Catechol O-methyltransferase 2.1.1.6 0.838
3ozr OZRCatechol O-methyltransferase 2.1.1.6 0.782
5fhq DNCCatechol O-methyltransferase 2.1.1.6 0.766
2zvj KOMCatechol O-methyltransferase 2.1.1.6 0.765
3v8v SAMRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.718
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.717
2cl5 BIECatechol O-methyltransferase 2.1.1.6 0.699
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.697
4wec NADShort chain dehydrogenase / 0.693
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.691
2o07 MTASpermidine synthase 2.5.1.16 0.689
1g60 SAMModification methylase MboII 2.1.1.72 0.687
1boo SAHModification methylase PvuII 2.1.1.113 0.685
4yac NAIC alpha-dehydrogenase / 0.680
4mwz SAMPhosphoethanolamine N-methyltransferase, putative / 0.679
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.679
2o06 MTASpermidine synthase 2.5.1.16 0.676
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.675
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.675
3g07 SAM7SK snRNA methylphosphate capping enzyme 2.1.1 0.674
2qa2 FADPolyketide oxygenase CabE / 0.673
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.672
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.670
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.669
3i0a DBHNeutrophil gelatinase-associated lipocalin / 0.668
4xcx SAHSmall RNA 2'-O-methyltransferase / 0.667
3b3f SAHHistone-arginine methyltransferase CARM1 / 0.665
4gbe SAHDNA adenine methylase 2.1.1.72 0.665
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.664
1eg2 MTAModification methylase RsrI 2.1.1.72 0.660
3duw SAHO-methyltransferase, putative / 0.656
3ea4 FABAcetolactate synthase, chloroplastic 2.2.1.6 0.656
4k5r FADOxygenase / 0.656
1qao SAMrRNA adenine N-6-methyltransferase 2.1.1.184 0.655
4mb2 ATPUncharacterized protein / 0.655
4o29 SAHProtein-L-isoaspartate O-methyltransferase / 0.654
4oa5 SAHO-methyltransferase family protein / 0.654
4wxx SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.654
5adv DBSEnterochelin uptake periplasmic binding protein / 0.654
1v59 NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
2cul FADGidA-related protein / 0.652
2hmv ADPKtr system potassium uptake protein A / 0.652
2hnk SAHSAM-dependent O-methyltransferase / 0.651
3rw9 DSHSpermidine synthase 2.5.1.16 0.651