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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3kmw ATP Integrin-linked protein kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 1.055
3rep ATPIntegrin-linked protein kinase 2.7.11.1 0.995
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.753
4wuc ANPDNA gyrase subunit B / 0.744
1nhh ANPDNA mismatch repair protein MutL / 0.717
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.717
4wud ANPDNA gyrase subunit B / 0.717
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.714
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.698
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.693
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.684
3vth APCCarbamoyltransferase / 0.683
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.683
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.682
1xjk DGTVitamin B12-dependent ribonucleotide reductase / 0.680
4ipe ANPTNF receptor-associated protein 1 / 0.679
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.677
3ork AGSSerine/threonine protein kinase / 0.675
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.672
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.672
4dwb 0M7Farnesyl pyrophosphate synthase / 0.672
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.671
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.670
4ivg ANPTNF receptor-associated protein 1 / 0.669
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.668
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.668
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.666
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.666
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.666
1xjj DGTVitamin B12-dependent ribonucleotide reductase / 0.665
4z17 PEPEnolase / 0.663
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.662
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.661
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.661
1peq TTPRibonucleoside-diphosphate reductase 2 subunit alpha 1.17.4.1 0.658
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.657
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.657
3krf DSTGeranyl diphosphate synthase large subunit / 0.656
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.656
1rqj IPEFarnesyl diphosphate synthase 2.5.1.10 0.655
1svw GTPProbable GTP-binding protein EngB / 0.654
3ta2 ATPNitrogen regulatory protein P-II (GlnB-3) / 0.653
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.652
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.652
4xcl AGSHeat shock cognate 90 kDa protein / 0.652
1ol6 ATPAurora kinase A 2.7.11.1 0.651
2ogi GDPUncharacterized protein / 0.651
4b8w GDPGDP-L-fucose synthase 1.1.1.271 0.651
2xk2 ADPHeat shock protein HSP 90-alpha / 0.650
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.650