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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3kjr NAP Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 1.143
8dfr NDPDihydrofolate reductase 1.5.1.3 0.921
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.911
3nxx NDPDihydrofolate reductase 1.5.1.3 0.908
3d84 NDPDihydrofolate reductase 1.5.1.3 0.880
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.871
2w3b NDPDihydrofolate reductase 1.5.1.3 0.859
1dr2 TAPDihydrofolate reductase 1.5.1.3 0.858
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.844
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.841
3tqa NDPDihydrofolate reductase / 0.839
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.823
5ecc NAPDehydrofolate reductase type I / 0.820
1drh NAPDihydrofolate reductase 1.5.1.3 0.797
4m6j NDPDihydrofolate reductase 1.5.1.3 0.793
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.788
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.788
2cig 1DGDihydrofolate reductase 1.5.1.3 0.780
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.779
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.767
1m78 NDPDihydrofolate reductase 1.5.1.3 0.767
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.766
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.749
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.733
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.727
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.720
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.714
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.702
3dg8 NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.698
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.690
3qls NDPDihydrofolate reductase 1.5.1.3 0.687
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.676
3qlr NDPDihydrofolate reductase 1.5.1.3 0.674
4ha9 NDP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 1.1.1.302 0.664
5a02 NAPGlucose-fructose oxidoreductase / 0.657
5a03 NDPGlucose-fructose oxidoreductase / 0.657
2azn NAP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase / 0.656
1juv NDPDihydrofolate reductase 1.5.1.3 0.650