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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eps ATP Isocitrate dehydrogenase kinase/phosphatase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3eps ATPIsocitrate dehydrogenase kinase/phosphatase / 1.000
3g8d ADPBiotin carboxylase 6.3.4.14 0.726
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.720
3wnz ADPAlanine--anticapsin ligase / 0.703
4ffm ADPUncharacterized protein / 0.700
2vqd AP2Biotin carboxylase 6.3.4.14 0.690
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.690
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.685
4mv8 ACPBiotin carboxylase 6.3.4.14 0.685
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.681
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.679
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.679
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.676
2p0a ANPSynapsin-3 / 0.675
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.675
5c1o ANPD-alanine--D-alanine ligase / 0.674
2zdg ADPD-alanine--D-alanine ligase / 0.673
3r5f ATPD-alanine--D-alanine ligase / 0.673
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.673
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.671
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.670
4mv1 ADPBiotin carboxylase 6.3.4.14 0.669
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.666
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.665
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.665
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.665
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.665
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.664
1pk8 ATPSynapsin-1 / 0.662
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.662
2pyw ADPMethylthioribose kinase 2.7.1.100 0.660
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.659
4ffl ADPUncharacterized protein / 0.659
4lrj ANPUncharacterized protein / 0.658
2j9g ADPBiotin carboxylase 6.3.4.14 0.657
1px2 ATPSynapsin-1 / 0.656
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4ozn ATPAmmonium transporter / 0.654
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.653
5c1p ADPD-alanine--D-alanine ligase / 0.652
2cx8 SAHRibosomal RNA small subunit methyltransferase E / 0.651
4fu0 ADPD-alanine--D-alanine ligase / 0.651
1cm8 ANPMitogen-activated protein kinase 12 / 0.650
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.650