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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cok ANP Serine/threonine-protein kinase PLK4 2.7.11.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.875
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.717
4qml ANPSerine/threonine-protein kinase 24 2.7.11.1 0.713
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.712
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.709
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.694
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.692
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.692
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.691
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.685
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.678
3b2t M33Fibroblast growth factor receptor 2 / 0.677
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.676
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.673
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.672
3c4w ATPRhodopsin kinase / 0.672
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.671
4lv8 ADPRhoptry protein 5 C / 0.671
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.670
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.670
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.669
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.667
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.665
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.663
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.661
4ax8 ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.661
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.660
5dr2 ATPAurora kinase A 2.7.11.1 0.660
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.657
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.657
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.656
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.656
4j95 ACPFibroblast growth factor receptor 2 / 0.656
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.655
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.655
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.654
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.652
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.652
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.651