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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x19 GTP GTP-binding nuclear protein GSP1/CNR1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2x19 GTPGTP-binding nuclear protein GSP1/CNR1 / 1.213
3wyg GTPGTP-binding nuclear protein GSP1/CNR1 / 0.822
3wyf GTPGTP-binding nuclear protein / 0.776
3c15 GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.760
3w3z GTPGTP-binding nuclear protein Ran / 0.747
4ol0 GTPGTP-binding nuclear protein Ran / 0.746
1wa5 GTPGTP-binding nuclear protein Ran / 0.739
3nbz GTPGTP-binding nuclear protein Ran / 0.729
2bku GTPGTP-binding nuclear protein Ran / 0.724
4o25 GTPGTP-binding protein Rheb / 0.722
4kvg GTPRas-related protein Rap-1A / 0.720
3a6p GTPGTP-binding nuclear protein Ran / 0.716
3c16 GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.715
3kz1 GSPTransforming protein RhoA / 0.710
1cul GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.702
1yzq GNPRas-related protein Rab-6A / 0.702
2q3f GNPRas-related GTP-binding protein D / 0.701
2qtv GNPSmall COPII coat GTPase SAR1 3.6.5 0.697
3tso GNPRas-related protein Rab-25 / 0.693
2ffq GSPRas-related protein Rab-6B / 0.692
4tq9 GDPGTPase KRas / 0.691
1t91 GTPRas-related protein Rab-7a / 0.690
2j5x GSPADP-ribosylation factor 6 / 0.690
1oix GDPRas-related protein Rab-11A / 0.689
3lbn GNPGTPase HRas / 0.688
4nyj GNPGTPase HRas / 0.688
4l9w GNPGTPase HRas / 0.686
5b2z GNPGTPase HRas / 0.684
3qe0 GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.683
2rgc GNPGTPase HRas / 0.682
1zbd GTPRas-related protein Rab-3A / 0.681
2zet GTPRas-related protein Rab-27B / 0.681
4dsn GCPGTPase KRas / 0.680
3kkq GDPRas-related protein M-Ras / 0.679
4dlw GNPGTPase HRas / 0.679
4hdo GNPRas-related protein Rap-1b / 0.679
2olr ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.678
3cx8 GSPGuanine nucleotide-binding protein subunit alpha-13 / 0.677
3tkl GTPRas-related protein Rab-1A / 0.677
1zc3 GNPRas-related protein Ral-A / 0.676
3qpv ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.676
4dlz GNPGTPase HRas / 0.676
1zc4 GNPRas-related protein Ral-A / 0.674
3ea5 GDPGTP-binding nuclear protein Ran / 0.674
3qbt GNPRas-related protein Rab-8A / 0.673
4dlt GNPGTPase HRas / 0.673
4fid GDPG protein alpha subunit, putative / 0.673
2c5l GTPGTPase HRas / 0.672
4k81 GTPGTPase HRas / 0.672
2xtz GSPGuanine nucleotide-binding protein alpha-1 subunit / 0.669
3oiw GNPGTPase HRas / 0.669
4pao GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.669
1svm ATPLarge T antigen 3.6.4 0.668
4lhw GNPRas-related protein Rab-8A / 0.668
1k5d GNPGTP-binding nuclear protein Ran / 0.667
2dpx GDPGTP-binding protein RAD / 0.667
3tgp GNPGTPase HRas / 0.667
3x1z GNPRas-related protein Rap-1b / 0.666
4d0l GSPRas-related protein Rab-11A / 0.666
3i3s GNPGTPase HRas / 0.665
5jlj GNPGTP-binding nuclear protein Ran / 0.665
1ky2 GNPGTP-binding protein YPT7 / 0.663
3cph GDPRas-related protein SEC4 / 0.663
3b1x GNPFerrous iron transport protein B / 0.662
4dvg GSPRho family GTPase / 0.662
4gzl GNPRas-related C3 botulinum toxin substrate 1 / 0.662
2w2v GTPRas-related C3 botulinum toxin substrate 2 / 0.661
3bbp GTPRas-related protein Rab-6A / 0.661
4jsy GTPMetallophosphoesterase / 0.661
1khb GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.660
1yhn GTPRas-related protein Rab-7a / 0.660
3bc1 GNPRas-related protein Rab-27A / 0.660
3v4f GNPGTPase HRas / 0.660
2gcp GSPRho-related GTP-binding protein RhoC / 0.659
3oiv GNPGTPase HRas / 0.659
2jj2 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.658
1xef ATPAlpha-hemolysin translocation ATP-binding protein HlyB / 0.657
1xts GTPGTP-binding protein Rheb / 0.657
2cls GTPRho-related GTP-binding protein Rho6 / 0.657
3l8y GNPGTPase HRas / 0.657
1azt GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.656
1mmg AGSMyosin-2 heavy chain / 0.656
4dxa GSPRas-related protein Rap-1b / 0.656
5dif GNPGTP-binding nuclear protein Ran / 0.656
4nyi GNPGTPase HRas / 0.655
2fju GSPRas-related C3 botulinum toxin substrate 1 / 0.653
3kuc GDPRas-related protein Rap-1A / 0.653
4pan GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.653
4qm6 GTPMetallophosphoesterase / 0.653
4tlb AGSCircadian clock protein kinase KaiC 2.7.11.1 0.653
3kud GDPGTPase HRas / 0.652
3qbv GDPCell division control protein 42 homolog / 0.652
1gil GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.651
2gvd GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.651
4o2r GDPGTP-binding protein Rheb / 0.651
2rgg GNPGTPase HRas / 0.650
3sbd GNPRas-related C3 botulinum toxin substrate 1 / 0.650